Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects
<p>An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2008-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v04p0362.htm |
| _version_ | 1811303694671544320 |
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| author | R. Vasudevan, Patimah Ismail, Johnson Stanslas, Norashikin Shamsudin, Aisyah binti Ali |
| author_facet | R. Vasudevan, Patimah Ismail, Johnson Stanslas, Norashikin Shamsudin, Aisyah binti Ali |
| author_sort | R. Vasudevan, Patimah Ismail, Johnson Stanslas, Norashikin Shamsudin, Aisyah binti Ali |
| collection | DOAJ |
| description | <p>An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% <i>vs</i>. 29.33%; <i>P­</i>=0.029) and in hypertensive with T2DM subjects (46.15% <i>vs</i>. 29.33%; <i>P</i>=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects.</p> |
| first_indexed | 2024-04-13T07:52:37Z |
| format | Article |
| id | doaj.art-78705f7bb1ab424384b66ddb402b1341 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-13T07:52:37Z |
| publishDate | 2008-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-78705f7bb1ab424384b66ddb402b13412022-12-22T02:55:30ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882008-01-0146362367Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian SubjectsR. Vasudevan, Patimah Ismail, Johnson Stanslas, Norashikin Shamsudin, Aisyah binti Ali<p>An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% <i>vs</i>. 29.33%; <i>P­</i>=0.029) and in hypertensive with T2DM subjects (46.15% <i>vs</i>. 29.33%; <i>P</i>=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects.</p>http://www.biolsci.org/v04p0362.htm |
| spellingShingle | R. Vasudevan, Patimah Ismail, Johnson Stanslas, Norashikin Shamsudin, Aisyah binti Ali Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects International Journal of Biological Sciences |
| title | Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects |
| title_full | Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects |
| title_fullStr | Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects |
| title_full_unstemmed | Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects |
| title_short | Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects |
| title_sort | association of insertion deletion polymorphism of alpha adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in malaysian subjects |
| url | http://www.biolsci.org/v04p0362.htm |
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