Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment

Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment

Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of Hsp90-dependent client proteins through the ubiq...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Yong Li, Dongmei Zhang, Jun Xu, Junmin Shi, Lei Jiang, Nan Yao, Wencai Ye
Format:	Artykuł
Język:	English
Wydane:	Elsevier 2012-06-01
Seria:	Acta Pharmaceutica Sinica B
Hasła przedmiotowe:	Heat shock protein 90 (Hsp90) Tumor Hsp90 inhibitors Geldanamycin
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S2211383512000639

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