Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis
Abstract Background and Aim Toxoplasmosis is the most widespread zoonotic disease that affects one‐third of the world's population, and imposes a major public health problem worldwide. This study aimed to assess the prevalence of toxoplasmosis among patients with neuropsychiatric patients. Meth...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1319 |
| _version_ | 1827912679590723584 |
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| author | Habtye Bisetegn Habtu Debash Hussen Ebrahim Naunian Mahmood Alemu Gedefie Mihret Tilahun Ermiyas Alemayehu Ousman Mohammed Daniel Getacher Feleke |
| author_facet | Habtye Bisetegn Habtu Debash Hussen Ebrahim Naunian Mahmood Alemu Gedefie Mihret Tilahun Ermiyas Alemayehu Ousman Mohammed Daniel Getacher Feleke |
| author_sort | Habtye Bisetegn |
| collection | DOAJ |
| description | Abstract Background and Aim Toxoplasmosis is the most widespread zoonotic disease that affects one‐third of the world's population, and imposes a major public health problem worldwide. This study aimed to assess the prevalence of toxoplasmosis among patients with neuropsychiatric patients. Methods Electronic databases PubMed, Google Scholar, Web of Science, Research Gate, and Scopus were thoroughly searched from February to March 2022 to identify all relevant studies. The quality of studies was evaluated using the Newcastle−Ottawa quality scale for case‐control and cross‐sectional studies. Statistical analysis was done using STATA version 12 software. A random effect model was used to compute the global pooled seroprevalence of Toxoplasma gondii infection. Heterogeneity was quantified by using I2 value. Subgroup analysis was done, and publication bias was assessed using a funnel plot and Egger's test. Result Of 1250 studies, 49 containing 21,093 participants and conducted in 18 countries were included. The global pooled seroprevalence of T. gondii IgG antibody was 38.27% (95% CI: 32.04−44.9) among neuropsychiatric patients and 25.31% (95% CI: 21.53−29.08) in healthy controls with substantial heterogeneity of 98.3%. The prevalence of T. gondii IgG antibody was higher in males (17.52%) than in females (12.35%) neuropsychiatric patients. The highest pooled prevalence of T. gondii IgG antibody was in Europe (57%) followed by Africa (45.25%) and Asia (43%). Time based analysis showed the highest pooled prevalence of T. gondii IgG antibody in 2012−2016 (41.16%). The global pooled seroprevalence T. gondii IgM antibody among neuropsychiatric patients and healthy controls was 6.78% (95% CI: 4.87−8.69) and 3.13% (95% CI: 2.02−4.24), respectively. Conclusion The pooled prevalence of chronic and acute T. gondii infection among neuropsychiatric patients was 38.27% and 6.78%, respectively. This showed a high burden of toxoplasmosis among neurological and psychiatric patients and urges routine screening of those patients and providing appropriate treatment. It also indicates the need for different stakeholders to develop targeted prevention and control strategies for T. gondii infection. |
| first_indexed | 2024-03-13T02:20:04Z |
| format | Article |
| id | doaj.art-7872018862164846954c5617a75cd071 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-13T02:20:04Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-7872018862164846954c5617a75cd0712023-06-30T10:20:50ZengWileyHealth Science Reports2398-88352023-06-0166n/an/a10.1002/hsr2.1319Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysisHabtye Bisetegn0Habtu Debash1Hussen Ebrahim2Naunian Mahmood3Alemu Gedefie4Mihret Tilahun5Ermiyas Alemayehu6Ousman Mohammed7Daniel Getacher Feleke8Department of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Zoology University of Sargodha Sargodha PakistanDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Microbiology, Immunology and Parasitology, College of Health Sciences Addis Ababa University Addis Ababa EthiopiaAbstract Background and Aim Toxoplasmosis is the most widespread zoonotic disease that affects one‐third of the world's population, and imposes a major public health problem worldwide. This study aimed to assess the prevalence of toxoplasmosis among patients with neuropsychiatric patients. Methods Electronic databases PubMed, Google Scholar, Web of Science, Research Gate, and Scopus were thoroughly searched from February to March 2022 to identify all relevant studies. The quality of studies was evaluated using the Newcastle−Ottawa quality scale for case‐control and cross‐sectional studies. Statistical analysis was done using STATA version 12 software. A random effect model was used to compute the global pooled seroprevalence of Toxoplasma gondii infection. Heterogeneity was quantified by using I2 value. Subgroup analysis was done, and publication bias was assessed using a funnel plot and Egger's test. Result Of 1250 studies, 49 containing 21,093 participants and conducted in 18 countries were included. The global pooled seroprevalence of T. gondii IgG antibody was 38.27% (95% CI: 32.04−44.9) among neuropsychiatric patients and 25.31% (95% CI: 21.53−29.08) in healthy controls with substantial heterogeneity of 98.3%. The prevalence of T. gondii IgG antibody was higher in males (17.52%) than in females (12.35%) neuropsychiatric patients. The highest pooled prevalence of T. gondii IgG antibody was in Europe (57%) followed by Africa (45.25%) and Asia (43%). Time based analysis showed the highest pooled prevalence of T. gondii IgG antibody in 2012−2016 (41.16%). The global pooled seroprevalence T. gondii IgM antibody among neuropsychiatric patients and healthy controls was 6.78% (95% CI: 4.87−8.69) and 3.13% (95% CI: 2.02−4.24), respectively. Conclusion The pooled prevalence of chronic and acute T. gondii infection among neuropsychiatric patients was 38.27% and 6.78%, respectively. This showed a high burden of toxoplasmosis among neurological and psychiatric patients and urges routine screening of those patients and providing appropriate treatment. It also indicates the need for different stakeholders to develop targeted prevention and control strategies for T. gondii infection.https://doi.org/10.1002/hsr2.1319global prevalenceneuropsychiatric disorderpsychiatric patientsToxoplasma gondiitoxoplasmosis |
| spellingShingle | Habtye Bisetegn Habtu Debash Hussen Ebrahim Naunian Mahmood Alemu Gedefie Mihret Tilahun Ermiyas Alemayehu Ousman Mohammed Daniel Getacher Feleke Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis Health Science Reports global prevalence neuropsychiatric disorder psychiatric patients Toxoplasma gondii toxoplasmosis |
| title | Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis |
| title_full | Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis |
| title_fullStr | Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis |
| title_full_unstemmed | Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis |
| title_short | Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis |
| title_sort | global seroprevalence of toxoplasma gondii infection among patients with mental and neurological disorders a systematic review and meta analysis |
| topic | global prevalence neuropsychiatric disorder psychiatric patients Toxoplasma gondii toxoplasmosis |
| url | https://doi.org/10.1002/hsr2.1319 |
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