Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
BackgroundAcute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1046839/full |
| _version_ | 1798016535119265792 |
|---|---|
| author | Yujuan Yuan Yiping Ma Zulipiya Aili Muyesai Nijiati |
| author_facet | Yujuan Yuan Yiping Ma Zulipiya Aili Muyesai Nijiati |
| author_sort | Yujuan Yuan |
| collection | DOAJ |
| description | BackgroundAcute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed to investigate the changes in Extracellular vesicle (EV)-associated miR-126 levels in the coronary blood of patients with AMI to explore the relationship between miR-126 levels and AMI.Materials and methodsWe analyzed EV-associated miR-126 in the coronary blood of patients with AMI and stable coronary artery disease (SCAD) using quantitative reverse transcription polymerase chain reaction (qRT-PCR).ResultsWe tested the coronary blood of 20 patients with AMI and 20 with SCAD. The mean age of the patients was 58.8 ± 10.3 years and 32 (80%) were men. We observed that the EV-associated miR-126 levels were lower in patients with AMI [median = 0.13; interquartile range (IQR): 0.08–0.22] than in patients with SCAD (median = 0.37; IQR: 0.26–0.48) (P < 0.001). In addition, the levels of miR-126 were negatively associated with the Thrombolysis in Myocardial Infarction (TIMI) score (r = −0.66, P = 0.001).ConclusionReduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events. |
| first_indexed | 2024-04-11T15:52:23Z |
| format | Article |
| id | doaj.art-78724b76e9f148048d98eeffa0028f5a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T15:52:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-78724b76e9f148048d98eeffa0028f5a2022-12-22T04:15:16ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10468391046839Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective studyYujuan Yuan0Yiping Ma1Zulipiya Aili2Muyesai Nijiati3Department of Cardiology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, ChinaXinjiang Emergency Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, ChinaXinjiang Emergency Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, ChinaXinjiang Emergency Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, ChinaBackgroundAcute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed to investigate the changes in Extracellular vesicle (EV)-associated miR-126 levels in the coronary blood of patients with AMI to explore the relationship between miR-126 levels and AMI.Materials and methodsWe analyzed EV-associated miR-126 in the coronary blood of patients with AMI and stable coronary artery disease (SCAD) using quantitative reverse transcription polymerase chain reaction (qRT-PCR).ResultsWe tested the coronary blood of 20 patients with AMI and 20 with SCAD. The mean age of the patients was 58.8 ± 10.3 years and 32 (80%) were men. We observed that the EV-associated miR-126 levels were lower in patients with AMI [median = 0.13; interquartile range (IQR): 0.08–0.22] than in patients with SCAD (median = 0.37; IQR: 0.26–0.48) (P < 0.001). In addition, the levels of miR-126 were negatively associated with the Thrombolysis in Myocardial Infarction (TIMI) score (r = −0.66, P = 0.001).ConclusionReduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1046839/fullacute myocardial infarction (AMI)microparticles (MPs)miR-126coronary bloodTIMI scorethrombosis |
| spellingShingle | Yujuan Yuan Yiping Ma Zulipiya Aili Muyesai Nijiati Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study Frontiers in Cardiovascular Medicine acute myocardial infarction (AMI) microparticles (MPs) miR-126 coronary blood TIMI score thrombosis |
| title | Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study |
| title_full | Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study |
| title_fullStr | Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study |
| title_full_unstemmed | Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study |
| title_short | Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study |
| title_sort | reductions in extracellular vesicle associated microrna 126 levels in coronary blood after acute myocardial infarction a retrospective study |
| topic | acute myocardial infarction (AMI) microparticles (MPs) miR-126 coronary blood TIMI score thrombosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1046839/full |
| work_keys_str_mv | AT yujuanyuan reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy AT yipingma reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy AT zulipiyaaili reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy AT muyesainijiati reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy |