The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabo...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2021-01-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2020-0129.pdf |
| _version_ | 1818451184774545408 |
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| author | Erica Jennison Christopher D. Byrne |
| author_facet | Erica Jennison Christopher D. Byrne |
| author_sort | Erica Jennison |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD. |
| first_indexed | 2024-12-14T21:03:10Z |
| format | Article |
| id | doaj.art-78758820c7fc418e9b94dbe13b712ce4 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-14T21:03:10Z |
| publishDate | 2021-01-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-78758820c7fc418e9b94dbe13b712ce42022-12-21T22:47:32ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2021-01-01271224310.3350/cmh.2020.01291568The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver diseaseErica Jennison0Christopher D. Byrne1 Department of Chemical Pathology, Southampton General Hospital, University Hospital Southampton, Southampton, UK Department of Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UKNon-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD.http://e-cmh.org/upload/pdf/cmh-2020-0129.pdfnon-alcoholic fatty liver diseasegastrointestinal microbiomedysbiosisdiet |
| spellingShingle | Erica Jennison Christopher D. Byrne The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease Clinical and Molecular Hepatology non-alcoholic fatty liver disease gastrointestinal microbiome dysbiosis diet |
| title | The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease |
| title_full | The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease |
| title_fullStr | The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease |
| title_full_unstemmed | The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease |
| title_short | The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease |
| title_sort | role of the gut microbiome and diet in the pathogenesis of non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease gastrointestinal microbiome dysbiosis diet |
| url | http://e-cmh.org/upload/pdf/cmh-2020-0129.pdf |
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