The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity
Introduction: Sodium sensitivity (SS) is a phenomenon in which significant changes in blood pressure (BP) are observed based on sodium intake. The renin–angiotensin–aldosterone system plays a critical role in sodium handling and hypertension. We identified the specific responses of renin and aldoste...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2014-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320314526437 |
| _version_ | 1797285473893220352 |
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| author | Sung Joon Shin ChiYeon Lim Sang Woo Oh Moo-Yong Rhee |
| author_facet | Sung Joon Shin ChiYeon Lim Sang Woo Oh Moo-Yong Rhee |
| author_sort | Sung Joon Shin |
| collection | DOAJ |
| description | Introduction: Sodium sensitivity (SS) is a phenomenon in which significant changes in blood pressure (BP) are observed based on sodium intake. The renin–angiotensin–aldosterone system plays a critical role in sodium handling and hypertension. We identified the specific responses of renin and aldosterone based on dietary sodium intake and revealed the relationship between these hormonal changes and dietary sodium intake in patients with SS. Materials and methods: In total, 61 subjects were available to analyze full data including plasma renin activity (PRA) and aldosterone. Participants were given a low-sodium DASH diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. Results: SS was found in five (14.71%) in normotensives, and 14 (51.85%) in hypertensives. In sodium-resistant (SR) subjects, both PRA and aldosterone decreased significantly after consuming HSD. Moreover, a significant correlation was observed between PRA and aldosterone in SR subjects. In contrast, only hypertensive subjects showed a marked fall in PRA after consuming HSD (1.299 ± 0.904 vs. 0.593 ± 0.479) among SS subjects. Conclusions: This study demonstrated the different responses of renin and aldosterone in SS and SR subjects based on dietary sodium intake whether or not they had hypertension. |
| first_indexed | 2024-03-07T18:03:40Z |
| format | Article |
| id | doaj.art-78763a9e79ee45d7871497a9af4d6e36 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:03:40Z |
| publishDate | 2014-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-78763a9e79ee45d7871497a9af4d6e362024-03-02T10:10:44ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-06-011510.1177/1470320314526437The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivitySung Joon Shin0ChiYeon Lim1Sang Woo Oh2Moo-Yong Rhee3Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University-Seoul, Republic of KoreaDepartment of Medicine, Graduate School, Dongguk University Ilsan Hospital, Dongguk University-Seoul, Republic of KoreaCenter for Obesity, Nutrition, and Metabolism, Department of Family Medicine, Dongguk University Ilsan Hospital, Republic of KoreaCardiovascular Center, Dongguk University Ilsan Hospital, Dongguk University-Seoul, Republic of KoreaIntroduction: Sodium sensitivity (SS) is a phenomenon in which significant changes in blood pressure (BP) are observed based on sodium intake. The renin–angiotensin–aldosterone system plays a critical role in sodium handling and hypertension. We identified the specific responses of renin and aldosterone based on dietary sodium intake and revealed the relationship between these hormonal changes and dietary sodium intake in patients with SS. Materials and methods: In total, 61 subjects were available to analyze full data including plasma renin activity (PRA) and aldosterone. Participants were given a low-sodium DASH diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. Results: SS was found in five (14.71%) in normotensives, and 14 (51.85%) in hypertensives. In sodium-resistant (SR) subjects, both PRA and aldosterone decreased significantly after consuming HSD. Moreover, a significant correlation was observed between PRA and aldosterone in SR subjects. In contrast, only hypertensive subjects showed a marked fall in PRA after consuming HSD (1.299 ± 0.904 vs. 0.593 ± 0.479) among SS subjects. Conclusions: This study demonstrated the different responses of renin and aldosterone in SS and SR subjects based on dietary sodium intake whether or not they had hypertension.https://doi.org/10.1177/1470320314526437 |
| spellingShingle | Sung Joon Shin ChiYeon Lim Sang Woo Oh Moo-Yong Rhee The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity Journal of the Renin-Angiotensin-Aldosterone System |
| title | The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity |
| title_full | The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity |
| title_fullStr | The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity |
| title_full_unstemmed | The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity |
| title_short | The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity |
| title_sort | unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity |
| url | https://doi.org/10.1177/1470320314526437 |
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