Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor
During spinal cord development, astrocyte precursors arise from neuroepithelial progenitors, delaminate from the ventricular zone, and migrate toward their final locations where they differentiate. Although the mechanisms underlying their early specification and late differentiation are being deciph...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716314024 |
| _version_ | 1819154924992200704 |
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| author | David Ohayon Alain Garcès Willy Joly Chadi Soukkarieh Tsuyoshi Takagi Jean-Charles Sabourin Eric Agius Douglas S. Darling Pascal De Santa Barbara Yujiro Higashi Claus C. Stolt Jean-Philippe Hugnot William D. Richardson Patrick Carroll Alexandre Pattyn |
| author_facet | David Ohayon Alain Garcès Willy Joly Chadi Soukkarieh Tsuyoshi Takagi Jean-Charles Sabourin Eric Agius Douglas S. Darling Pascal De Santa Barbara Yujiro Higashi Claus C. Stolt Jean-Philippe Hugnot William D. Richardson Patrick Carroll Alexandre Pattyn |
| author_sort | David Ohayon |
| collection | DOAJ |
| description | During spinal cord development, astrocyte precursors arise from neuroepithelial progenitors, delaminate from the ventricular zone, and migrate toward their final locations where they differentiate. Although the mechanisms underlying their early specification and late differentiation are being deciphered, less is known about the temporal control of their migration. Here, we show that the epithelial-mesenchymal transition regulator Zeb1 is expressed in glial precursors and report that loss of Zeb1 function specifically delays the onset of astrocyte precursor delamination from the ventricular zone, correlating with transient deregulation of the adhesion protein Cadherin-1. Consequently, astrocyte precursor invasion into the Zeb1−/− mutant white matter is delayed, and induction of their differentiation is postponed. These findings illustrate how fine regulation of adhesive properties influences the onset of neural precursor migration and further support the notion that duration of exposure of migrating astrocyte precursors to environmental cues and/or their correct positioning influence the timing of their differentiation. |
| first_indexed | 2024-12-22T15:28:49Z |
| format | Article |
| id | doaj.art-787670c4793c4033a38c325536f79486 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-22T15:28:49Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-787670c4793c4033a38c325536f794862022-12-21T18:21:24ZengElsevierCell Reports2211-12472016-11-011761473148110.1016/j.celrep.2016.10.016Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription FactorDavid Ohayon0Alain Garcès1Willy Joly2Chadi Soukkarieh3Tsuyoshi Takagi4Jean-Charles Sabourin5Eric Agius6Douglas S. Darling7Pascal De Santa Barbara8Yujiro Higashi9Claus C. Stolt10Jean-Philippe Hugnot11William D. Richardson12Patrick Carroll13Alexandre Pattyn14INSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceDepartment of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, JapanINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceUniversité de Toulouse, Centre National de la Recherche Scientifique (CNRS), CBD-UMR5547, 31062 Toulouse, FranceDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202, USAPhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier, 34295 Montpellier, FranceDepartment of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, JapanInstitut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceWolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UKINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceINSERM U1051, Institut des Neurosciences de Montpellier, 34091 Montpellier, FranceDuring spinal cord development, astrocyte precursors arise from neuroepithelial progenitors, delaminate from the ventricular zone, and migrate toward their final locations where they differentiate. Although the mechanisms underlying their early specification and late differentiation are being deciphered, less is known about the temporal control of their migration. Here, we show that the epithelial-mesenchymal transition regulator Zeb1 is expressed in glial precursors and report that loss of Zeb1 function specifically delays the onset of astrocyte precursor delamination from the ventricular zone, correlating with transient deregulation of the adhesion protein Cadherin-1. Consequently, astrocyte precursor invasion into the Zeb1−/− mutant white matter is delayed, and induction of their differentiation is postponed. These findings illustrate how fine regulation of adhesive properties influences the onset of neural precursor migration and further support the notion that duration of exposure of migrating astrocyte precursors to environmental cues and/or their correct positioning influence the timing of their differentiation.http://www.sciencedirect.com/science/article/pii/S2211124716314024astrocyteoligodendrocyteZeb1Zeb2Cadherin-1Sox9GFAPcell migrationspinal corddevelopment |
| spellingShingle | David Ohayon Alain Garcès Willy Joly Chadi Soukkarieh Tsuyoshi Takagi Jean-Charles Sabourin Eric Agius Douglas S. Darling Pascal De Santa Barbara Yujiro Higashi Claus C. Stolt Jean-Philippe Hugnot William D. Richardson Patrick Carroll Alexandre Pattyn Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor Cell Reports astrocyte oligodendrocyte Zeb1 Zeb2 Cadherin-1 Sox9 GFAP cell migration spinal cord development |
| title | Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor |
| title_full | Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor |
| title_fullStr | Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor |
| title_full_unstemmed | Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor |
| title_short | Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor |
| title_sort | onset of spinal cord astrocyte precursor emigration from the ventricular zone involves the zeb1 transcription factor |
| topic | astrocyte oligodendrocyte Zeb1 Zeb2 Cadherin-1 Sox9 GFAP cell migration spinal cord development |
| url | http://www.sciencedirect.com/science/article/pii/S2211124716314024 |
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