Chiral Separation of Apremilast by Capillary Electrophoresis Using Succinyl-β-Cyclodextrin—Reversal of Enantiomer Elution Order by Cationic Capillary Coating

Chiral Separation of Apremilast by Capillary Electrophoresis Using Succinyl-β-Cyclodextrin—Reversal of Enantiomer Elution Order by Cationic Capillary Coating

A stereospecific capillary electrophoresis method was developed for the separation of the novel, antipsoriatic agent, apremilast (APR). Six anionic cyclodextrin (CD) derivatives were screened for their ability to discriminate between the uncharged enantiomers. Only succinyl-β-CD (Succ-β-CD) presente...

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Bibliographic Details
Main Authors: Zoltán-István Szabó, Beáta-Mária Benkő, Ágnes Bartalis-Fábián, Róbert Iványi, Erzsébet Varga, Levente Szőcs, Gergő Tóth
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
apremilast
reversal of enantiomeric elution order
cyclodextrin
CE
capillary coating
Online Access:https://www.mdpi.com/1420-3049/28/8/3310

Internet

https://www.mdpi.com/1420-3049/28/8/3310

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