The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review
Abstract Decellularized vascular matrix is a natural polymeric biomaterial that comes from arteries or veins which are removed the cellular contents by physical, chemical and enzymatic means, leaving only the cytoskeletal structure and extracellular matrix to achieve cell adhesion, proliferation and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BioMedical Engineering OnLine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12938-023-01120-z |
| _version_ | 1827916784757374976 |
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| author | Jingying Li Xiao Chen Miaoling Hu Jian Wei Minhai Nie Jiana Chen Xuqian Liu |
| author_facet | Jingying Li Xiao Chen Miaoling Hu Jian Wei Minhai Nie Jiana Chen Xuqian Liu |
| author_sort | Jingying Li |
| collection | DOAJ |
| description | Abstract Decellularized vascular matrix is a natural polymeric biomaterial that comes from arteries or veins which are removed the cellular contents by physical, chemical and enzymatic means, leaving only the cytoskeletal structure and extracellular matrix to achieve cell adhesion, proliferation and differentiation and creating a suitable microenvironment for their growth. In recent years, the decellularized vascular matrix has attracted much attention in the field of tissue repair and regenerative medicine due to its remarkable cytocompatibility, biodegradability and ability to induce tissue regeneration. Firstly, this review introduces its basic properties and preparation methods; then, it focuses on the application and research of composite scaffold materials based on decellularized vascular matrix in vascular tissue engineering in terms of current in vitro and in vivo studies, and briefly outlines its applications in other tissue engineering fields; finally, it looks into the advantages and drawbacks to be overcome in the application of decellularized vascular matrix materials. In conclusion, as a new bioactive material for building engineered tissue and repairing tissue defects, decellularized vascular matrix will be widely applied in prospect. |
| first_indexed | 2024-03-13T03:20:11Z |
| format | Article |
| id | doaj.art-787b4a5b298448d4b62c63d9095ef8ee |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-03-13T03:20:11Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-787b4a5b298448d4b62c63d9095ef8ee2023-06-25T11:23:14ZengBMCBioMedical Engineering OnLine1475-925X2023-06-0122111910.1186/s12938-023-01120-zThe application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a reviewJingying Li0Xiao Chen1Miaoling Hu2Jian Wei3Minhai Nie4Jiana Chen5Xuqian Liu6Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Stomatology Technology, School of Medical Technology, Sichuan College of Traditional MedicineDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityAbstract Decellularized vascular matrix is a natural polymeric biomaterial that comes from arteries or veins which are removed the cellular contents by physical, chemical and enzymatic means, leaving only the cytoskeletal structure and extracellular matrix to achieve cell adhesion, proliferation and differentiation and creating a suitable microenvironment for their growth. In recent years, the decellularized vascular matrix has attracted much attention in the field of tissue repair and regenerative medicine due to its remarkable cytocompatibility, biodegradability and ability to induce tissue regeneration. Firstly, this review introduces its basic properties and preparation methods; then, it focuses on the application and research of composite scaffold materials based on decellularized vascular matrix in vascular tissue engineering in terms of current in vitro and in vivo studies, and briefly outlines its applications in other tissue engineering fields; finally, it looks into the advantages and drawbacks to be overcome in the application of decellularized vascular matrix materials. In conclusion, as a new bioactive material for building engineered tissue and repairing tissue defects, decellularized vascular matrix will be widely applied in prospect.https://doi.org/10.1186/s12938-023-01120-zDecellularized vascular matrixExtracellular matrixVascular graftVascular scaffold |
| spellingShingle | Jingying Li Xiao Chen Miaoling Hu Jian Wei Minhai Nie Jiana Chen Xuqian Liu The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review BioMedical Engineering OnLine Decellularized vascular matrix Extracellular matrix Vascular graft Vascular scaffold |
| title | The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review |
| title_full | The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review |
| title_fullStr | The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review |
| title_full_unstemmed | The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review |
| title_short | The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review |
| title_sort | application of composite scaffold materials based on decellularized vascular matrix in tissue engineering a review |
| topic | Decellularized vascular matrix Extracellular matrix Vascular graft Vascular scaffold |
| url | https://doi.org/10.1186/s12938-023-01120-z |
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