Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies
Abstract Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex interaction between cancerous cells and the immune system. Recent studies have shown the significant function of exosomes in facilitating intercellular communication and...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13058-024-01810-z |
| _version_ | 1827300812137693184 |
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| author | Sahar Safaei Manouchehr Fadaee Omid Rahbar Farzam Amirhossein Yari Elham Poursaei Cynthia Aslan Sahar Samemaleki Dariush Shanehbandi Behzad Baradaran Tohid Kazemi |
| author_facet | Sahar Safaei Manouchehr Fadaee Omid Rahbar Farzam Amirhossein Yari Elham Poursaei Cynthia Aslan Sahar Samemaleki Dariush Shanehbandi Behzad Baradaran Tohid Kazemi |
| author_sort | Sahar Safaei |
| collection | DOAJ |
| description | Abstract Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex interaction between cancerous cells and the immune system. Recent studies have shown the significant function of exosomes in facilitating intercellular communication and their participation in the advancement of cancer. Tumor-derived exosomes have been identified as significant regulators in the context of breast cancer, playing a crucial role in modulating immune cell activity and contributing to the advancement of the illness. This study aims to investigate the many effects of tumor-derived exosomes on immune cells in the setting of breast cancer. Specifically, we will examine their role in influencing immune cell polarization, facilitating immunological evasion, and modifying the tumor microenvironment. Furthermore, we explore the nascent domain of exosomes produced from immune cells and their prospective involvement in the prevention of breast cancer. This paper focuses on new research that emphasizes the immunomodulatory characteristics of exosomes produced from immune cells. It also explores the possibility of these exosomes as therapeutic agents or biomarkers for the early identification and prevention of breast cancer. The exploration of the reciprocal connections between exosomes formed from tumors and immune cells, together with the rising significance of exosomes derived from immune cells, presents a potential avenue for the advancement of novel approaches in the field of breast cancer therapy and prevention. |
| first_indexed | 2024-04-24T16:12:11Z |
| format | Article |
| id | doaj.art-787c1871fc714c12af874bb31433dee3 |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-04-24T16:12:11Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-787c1871fc714c12af874bb31433dee32024-03-31T11:38:57ZengBMCBreast Cancer Research1465-542X2024-03-0126111410.1186/s13058-024-01810-zExploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategiesSahar Safaei0Manouchehr Fadaee1Omid Rahbar Farzam2Amirhossein Yari3Elham Poursaei4Cynthia Aslan5Sahar Samemaleki6Dariush Shanehbandi7Behzad Baradaran8Tohid Kazemi9Immunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesBiotechnology Research Center, Tabriz University of Medical SciencesResearch Center for Integrative Medicine in Aging, Tabriz University of Medical SciencesDepartment of Immunology, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesAbstract Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex interaction between cancerous cells and the immune system. Recent studies have shown the significant function of exosomes in facilitating intercellular communication and their participation in the advancement of cancer. Tumor-derived exosomes have been identified as significant regulators in the context of breast cancer, playing a crucial role in modulating immune cell activity and contributing to the advancement of the illness. This study aims to investigate the many effects of tumor-derived exosomes on immune cells in the setting of breast cancer. Specifically, we will examine their role in influencing immune cell polarization, facilitating immunological evasion, and modifying the tumor microenvironment. Furthermore, we explore the nascent domain of exosomes produced from immune cells and their prospective involvement in the prevention of breast cancer. This paper focuses on new research that emphasizes the immunomodulatory characteristics of exosomes produced from immune cells. It also explores the possibility of these exosomes as therapeutic agents or biomarkers for the early identification and prevention of breast cancer. The exploration of the reciprocal connections between exosomes formed from tumors and immune cells, together with the rising significance of exosomes derived from immune cells, presents a potential avenue for the advancement of novel approaches in the field of breast cancer therapy and prevention.https://doi.org/10.1186/s13058-024-01810-zBreast cancerTumor-derived exosomesImmune cellTumor microenvironmentImmune cell-derived exosomesImmunotherapy |
| spellingShingle | Sahar Safaei Manouchehr Fadaee Omid Rahbar Farzam Amirhossein Yari Elham Poursaei Cynthia Aslan Sahar Samemaleki Dariush Shanehbandi Behzad Baradaran Tohid Kazemi Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies Breast Cancer Research Breast cancer Tumor-derived exosomes Immune cell Tumor microenvironment Immune cell-derived exosomes Immunotherapy |
| title | Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies |
| title_full | Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies |
| title_fullStr | Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies |
| title_full_unstemmed | Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies |
| title_short | Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies |
| title_sort | exploring the dynamic interplay between exosomes and the immune tumor microenvironment implications for breast cancer progression and therapeutic strategies |
| topic | Breast cancer Tumor-derived exosomes Immune cell Tumor microenvironment Immune cell-derived exosomes Immunotherapy |
| url | https://doi.org/10.1186/s13058-024-01810-z |
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