Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates
The association between inflammation with depression and suicide has prompted many investigations of the potential contributors to inflammatory pathology in these psychiatric illnesses. However, a distillation of diverse clinical findings into an integrated framework of the possible involvement of m...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479471/full |
| _version_ | 1826923959031955456 |
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| author | Alessandra Costanza Alessandra Costanza Alessandra Costanza Andrea Amerio Andrea Amerio Andrea Aguglia Andrea Aguglia Luca Magnani Alberto Parise Khoa D. Nguyen Khoa D. Nguyen Isabella Berardelli Maurizio Pompili Mario Amore Mario Amore Gianluca Serafini Gianluca Serafini |
| author_facet | Alessandra Costanza Alessandra Costanza Alessandra Costanza Andrea Amerio Andrea Amerio Andrea Aguglia Andrea Aguglia Luca Magnani Alberto Parise Khoa D. Nguyen Khoa D. Nguyen Isabella Berardelli Maurizio Pompili Mario Amore Mario Amore Gianluca Serafini Gianluca Serafini |
| author_sort | Alessandra Costanza |
| collection | DOAJ |
| description | The association between inflammation with depression and suicide has prompted many investigations of the potential contributors to inflammatory pathology in these psychiatric illnesses. However, a distillation of diverse clinical findings into an integrated framework of the possible involvement of major physiological processes in the elicitation of pathological inflammation in depression and suicide has not yet been explored. Therefore, this review aims to provide a concise synthesis of notable clinical correlates of inflammatory pathology in subjects with various depressive and suicidal clinical subtypes into a mechanistic framework, which includes aberrant immune activation, deregulated neuroendocrine signaling, and impaired host-microbe interaction. These issues are of significant research interest as their possible interplays might be involved in the development of distinct subtypes of depression and suicide. We conclude the review with discussion of a pathway-focused therapeutic approach to address inflammatory pathology in these psychiatric illnesses within the realm of personalized care for affected patients. |
| first_indexed | 2025-02-17T14:32:39Z |
| format | Article |
| id | doaj.art-787c94fd67f8480694d19de90ea97133 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2025-02-17T14:32:39Z |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-787c94fd67f8480694d19de90ea971332024-12-23T05:10:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14794711479471Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlatesAlessandra Costanza0Alessandra Costanza1Alessandra Costanza2Andrea Amerio3Andrea Amerio4Andrea Aguglia5Andrea Aguglia6Luca Magnani7Alberto Parise8Khoa D. Nguyen9Khoa D. Nguyen10Isabella Berardelli11Maurizio Pompili12Mario Amore13Mario Amore14Gianluca Serafini15Gianluca Serafini16Department of Psychiatry, Faculty of Medicine, Geneva University (UNIGE), Geneva, SwitzerlandDepartment of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), Lugano, SwitzerlandDepartment of Psychiatry, Adult Psychiatry Service, Geneva University Hospital (HUG), Geneva, SwitzerlandDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, ItalyIRCCS Polyclinic Hospital San Martino, Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, ItalyIRCCS Polyclinic Hospital San Martino, Genoa, ItalyDepartment of Psychiatry, San Maurizio Hospital of Bolzano, Bolzano, ItalyGeriatric-Rehabilitation Department, University Hospital of Parma, Parma, ItalyChinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, United States0Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Centre, Sant’Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy0Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Centre, Sant’Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, ItalyIRCCS Polyclinic Hospital San Martino, Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, ItalyDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, United StatesThe association between inflammation with depression and suicide has prompted many investigations of the potential contributors to inflammatory pathology in these psychiatric illnesses. However, a distillation of diverse clinical findings into an integrated framework of the possible involvement of major physiological processes in the elicitation of pathological inflammation in depression and suicide has not yet been explored. Therefore, this review aims to provide a concise synthesis of notable clinical correlates of inflammatory pathology in subjects with various depressive and suicidal clinical subtypes into a mechanistic framework, which includes aberrant immune activation, deregulated neuroendocrine signaling, and impaired host-microbe interaction. These issues are of significant research interest as their possible interplays might be involved in the development of distinct subtypes of depression and suicide. We conclude the review with discussion of a pathway-focused therapeutic approach to address inflammatory pathology in these psychiatric illnesses within the realm of personalized care for affected patients.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479471/fullsuicidesuicidal ideationsuicidal behaviorinflammationimmune systemneuroendocrine |
| spellingShingle | Alessandra Costanza Alessandra Costanza Alessandra Costanza Andrea Amerio Andrea Amerio Andrea Aguglia Andrea Aguglia Luca Magnani Alberto Parise Khoa D. Nguyen Khoa D. Nguyen Isabella Berardelli Maurizio Pompili Mario Amore Mario Amore Gianluca Serafini Gianluca Serafini Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates Frontiers in Immunology suicide suicidal ideation suicidal behavior inflammation immune system neuroendocrine |
| title | Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates |
| title_full | Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates |
| title_fullStr | Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates |
| title_full_unstemmed | Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates |
| title_short | Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates |
| title_sort | inflammatory pathology in depression and suicide a mechanistic distillation of clinical correlates |
| topic | suicide suicidal ideation suicidal behavior inflammation immune system neuroendocrine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479471/full |
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