Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
Abstract The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate im...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | Military Medical Research |
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| Online Access: | http://link.springer.com/article/10.1186/s40779-019-0222-9 |
| _version_ | 1818199134652334080 |
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| author | Jing-jing Ji Jie Fan |
| author_facet | Jing-jing Ji Jie Fan |
| author_sort | Jing-jing Ji |
| collection | DOAJ |
| description | Abstract The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing (NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury (ALI), lung fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer. |
| first_indexed | 2024-12-12T02:16:56Z |
| format | Article |
| id | doaj.art-787cbc2ba1094b889b7af94a68a7d667 |
| institution | Directory Open Access Journal |
| issn | 2054-9369 |
| language | English |
| last_indexed | 2024-12-12T02:16:56Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj.art-787cbc2ba1094b889b7af94a68a7d6672022-12-22T00:41:47ZengBMCMilitary Medical Research2054-93692019-10-016111010.1186/s40779-019-0222-9Discovering myeloid cell heterogeneity in the lung by means of next generation sequencingJing-jing Ji0Jie Fan1Department of Surgery, University of Pittsburgh School of MedicineDepartment of Surgery, University of Pittsburgh School of MedicineAbstract The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing (NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury (ALI), lung fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer.http://link.springer.com/article/10.1186/s40779-019-0222-9Acute lung injuryLung cancerLung diseaseLung developmentSingle-cell RNA sequencing |
| spellingShingle | Jing-jing Ji Jie Fan Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing Military Medical Research Acute lung injury Lung cancer Lung disease Lung development Single-cell RNA sequencing |
| title | Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing |
| title_full | Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing |
| title_fullStr | Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing |
| title_full_unstemmed | Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing |
| title_short | Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing |
| title_sort | discovering myeloid cell heterogeneity in the lung by means of next generation sequencing |
| topic | Acute lung injury Lung cancer Lung disease Lung development Single-cell RNA sequencing |
| url | http://link.springer.com/article/10.1186/s40779-019-0222-9 |
| work_keys_str_mv | AT jingjingji discoveringmyeloidcellheterogeneityinthelungbymeansofnextgenerationsequencing AT jiefan discoveringmyeloidcellheterogeneityinthelungbymeansofnextgenerationsequencing |