DNA methylation-based patterns for early diagnostic prediction and prognostic evaluation in colorectal cancer patients with high tumor mutation burden

DNA methylation-based patterns for early diagnostic prediction and prognostic evaluation in colorectal cancer patients with high tumor mutation burden

BackgroundImmune checkpoint inhibitor (ICI) therapy has proven to be a promising treatment for colorectal cancer (CRC). We aim to investigate the relationship between DNA methylation and tumor mutation burden (TMB) by integrating genomic and epigenetic profiles to precisely identify clinical benefit...

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Bibliographic Details
Main Authors: Hao Huang, Weifan Cao, Zhiping Long, Lei Kuang, Xi Li, Yifei Feng, Yuying Wu, Yang Zhao, Yinggang Chen, Peng Sun, Panxin Peng, Jinli Zhang, Lijun Yuan, Tianze Li, Huifang Hu, Gairui Li, Longkun Yang, Xing Zhang, Fulan Hu, Xizhuo Sun, Dongsheng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
TMB
DNA methylation
colorectal cancer
immunotherapy
TCGA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1030335/full

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