Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification

Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification

Abstract Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEVs) are known to exert immunosuppressive functions. This study showed that MSC-sEVs specifically convert T helper 17 (Th17) cells into IL-17 low-producer (ex-Th17) cells by degrading RAR-related orphan receptor γt (RORγ...

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Bibliographic Details
Main Authors: Sunyoung Jung, Sunho Lee, Hyun Je Kim, Sueon Kim, Ji Hwan Moon, Hyunwoo Chung, Seong-Jun Kang, Chung-Gyu Park
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-00949-7

Internet

https://doi.org/10.1038/s12276-023-00949-7

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