Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy
Plasma fibrinogen levels increase in response to infection, but they could also decrease due to degradation as in severe coagulopathy. We evaluated 60 septic patients with their CRP levels over 5.00 mg/dL. The patients were classified into three groups based on the ratio of the maximum or minimum fi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221101386 |
| _version_ | 1818206701139001344 |
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| author | Keisuke Mori Yasuyuki Tsujita MD, PhD Tetsunobu Yamane MD, PhD Yutaka Eguchi MD, PhD |
| author_facet | Keisuke Mori Yasuyuki Tsujita MD, PhD Tetsunobu Yamane MD, PhD Yutaka Eguchi MD, PhD |
| author_sort | Keisuke Mori |
| collection | DOAJ |
| description | Plasma fibrinogen levels increase in response to infection, but they could also decrease due to degradation as in severe coagulopathy. We evaluated 60 septic patients with their CRP levels over 5.00 mg/dL. The patients were classified into three groups based on the ratio of the maximum or minimum fibrinogen concentration within day 3 to the initial concentration on day 0: down-, flat, and uptrend groups (n = 15, 30, and 15, respectively). Both down- and flat trend groups showed reduced inflammatory markers on day 3, and the degree of platelet loss (10 3 /μL) and the mortality rate (%) were more remarkable in the downtrend group ( − 108 vs − 42 [ p = 0.026] and 46.7 vs 10.0 [ p = 0.027]). On day 0, in total 12 and 9 patients were diagnosed with non-overt DIC in the down- and uptrend groups, of which 5 (41.7%) and 1 (11.1%) died within 28 days after admission. In conclusion, decreasing fibrinogen levels in the ICU are associated with high mortality in patients with sepsis followed by decreasing platelet counts, even when they are diagnosed with non-overt DIC. |
| first_indexed | 2024-12-12T04:17:12Z |
| format | Article |
| id | doaj.art-787ea138eb1d492eae338c579be458cf |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-12T04:17:12Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-787ea138eb1d492eae338c579be458cf2022-12-22T00:38:25ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-05-012810.1177/10760296221101386Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced CoagulopathyKeisuke Mori0Yasuyuki Tsujita MD, PhD1Tetsunobu Yamane MD, PhD2Yutaka Eguchi MD, PhD3 School of Medicine, , Otsu, Shiga, Japan Emergency and Intensive Care Unit, , Otsu, Shiga, Japan Emergency and Intensive Care Unit, , Otsu, Shiga, Japan Department of Critical and Intensive Care Medicine, , Otsu, Shiga, JapanPlasma fibrinogen levels increase in response to infection, but they could also decrease due to degradation as in severe coagulopathy. We evaluated 60 septic patients with their CRP levels over 5.00 mg/dL. The patients were classified into three groups based on the ratio of the maximum or minimum fibrinogen concentration within day 3 to the initial concentration on day 0: down-, flat, and uptrend groups (n = 15, 30, and 15, respectively). Both down- and flat trend groups showed reduced inflammatory markers on day 3, and the degree of platelet loss (10 3 /μL) and the mortality rate (%) were more remarkable in the downtrend group ( − 108 vs − 42 [ p = 0.026] and 46.7 vs 10.0 [ p = 0.027]). On day 0, in total 12 and 9 patients were diagnosed with non-overt DIC in the down- and uptrend groups, of which 5 (41.7%) and 1 (11.1%) died within 28 days after admission. In conclusion, decreasing fibrinogen levels in the ICU are associated with high mortality in patients with sepsis followed by decreasing platelet counts, even when they are diagnosed with non-overt DIC.https://doi.org/10.1177/10760296221101386 |
| spellingShingle | Keisuke Mori Yasuyuki Tsujita MD, PhD Tetsunobu Yamane MD, PhD Yutaka Eguchi MD, PhD Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy Clinical and Applied Thrombosis/Hemostasis |
| title | Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy |
| title_full | Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy |
| title_fullStr | Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy |
| title_full_unstemmed | Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy |
| title_short | Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy |
| title_sort | decreasing plasma fibrinogen levels in the intensive care unit are associated with high mortality rates in patients with sepsis induced coagulopathy |
| url | https://doi.org/10.1177/10760296221101386 |
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