Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence
Despite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15384047.2023.2198479 |
| _version_ | 1797404047273099264 |
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| author | Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese |
| author_facet | Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese |
| author_sort | Orimisan Samuel Adekolujo |
| collection | DOAJ |
| description | Despite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approach to select patients who may benefit from more aggressive therapy has been suggested. Although studies have reported improved survival in PDAC and isolated pulmonary metastasis (ISP) compared to extrapulmonary metastases, such findings remain controversial. Furthermore, the added benefit of pulmonary metastasectomy and other lung-directed therapies remains unclear. In this review, we discuss the metastatic pattern of PDAC, evaluate the available evidence in the literature for improved survival in PDAC and ISP, evaluate the evidence for the added benefit of pulmonary metastasectomy and other lung-directed therapies, identify prognostic factors for survival, discuss the biological basis for the reported improved survival and identify areas for further research. |
| first_indexed | 2024-03-09T02:47:26Z |
| format | Article |
| id | doaj.art-7880abf3272e4970ad447f42a0a0fe35 |
| institution | Directory Open Access Journal |
| issn | 1538-4047 1555-8576 |
| language | English |
| last_indexed | 2024-03-09T02:47:26Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj.art-7880abf3272e4970ad447f42a0a0fe352023-12-05T15:58:14ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762023-12-0124110.1080/15384047.2023.21984792198479Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidenceOrimisan Samuel Adekolujo0Ahsan Wahab1Maxwell Oluwole Akanbi2Tolutope Oyasiji3Borys Hrinczenko4Olatunji Boladale Alese5Michigan State UniversityPrattville Baptist HospitalMichigan State UniversityWayne State UniversityMichigan State UniversityWinship Cancer Institute of Emory UniversityDespite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approach to select patients who may benefit from more aggressive therapy has been suggested. Although studies have reported improved survival in PDAC and isolated pulmonary metastasis (ISP) compared to extrapulmonary metastases, such findings remain controversial. Furthermore, the added benefit of pulmonary metastasectomy and other lung-directed therapies remains unclear. In this review, we discuss the metastatic pattern of PDAC, evaluate the available evidence in the literature for improved survival in PDAC and ISP, evaluate the evidence for the added benefit of pulmonary metastasectomy and other lung-directed therapies, identify prognostic factors for survival, discuss the biological basis for the reported improved survival and identify areas for further research.http://dx.doi.org/10.1080/15384047.2023.2198479pancreatic ductal adenocarcinomaisolated pulmonary metastasespulmonary metastasectomylung resectionsurvival |
| spellingShingle | Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence Cancer Biology & Therapy pancreatic ductal adenocarcinoma isolated pulmonary metastases pulmonary metastasectomy lung resection survival |
| title | Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence |
| title_full | Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence |
| title_fullStr | Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence |
| title_full_unstemmed | Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence |
| title_short | Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence |
| title_sort | isolated pulmonary metastases in pancreatic ductal adenocarcinoma a review of current evidence |
| topic | pancreatic ductal adenocarcinoma isolated pulmonary metastases pulmonary metastasectomy lung resection survival |
| url | http://dx.doi.org/10.1080/15384047.2023.2198479 |
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