Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea.

Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea.

<h4>Background</h4>Obstructive sleep apnea (OSA) is characterized by recurrent nocturnal hypoxia and sleep disruption. Sleep fragmentation caused hyperalgesia in volunteers, while nocturnal hypoxemia enhanced morphine analgesic potency in children with OSA. This evidence directly relates...

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Bibliographic Details
Main Authors: Anthony G Doufas, Lu Tian, Kevin A Padrez, Puntarica Suwanprathes, James A Cardell, Holden T Maecker, Periklis Panousis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382975/?tool=EBI

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