Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID
SARS-CoV-2, responsible for the global COVID-19 pandemic, has manifested significant cardiovascular implications for the infected population. These cardiovascular repercussions not only linger beyond the initial phase of illness but have also been observed in individuals who remain asymptomatic. Thi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1268571/full |
| _version_ | 1827337659478966272 |
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| author | Roba Hamed Mostafa Roba Hamed Mostafa Ahmed Moustafa Ahmed Moustafa Ahmed Moustafa |
| author_facet | Roba Hamed Mostafa Roba Hamed Mostafa Ahmed Moustafa Ahmed Moustafa Ahmed Moustafa |
| author_sort | Roba Hamed Mostafa |
| collection | DOAJ |
| description | SARS-CoV-2, responsible for the global COVID-19 pandemic, has manifested significant cardiovascular implications for the infected population. These cardiovascular repercussions not only linger beyond the initial phase of illness but have also been observed in individuals who remain asymptomatic. This extended and pervasive impact is often called the post-acute COVID-19 syndrome (PACS) or “Long COVID”. With the number of confirmed global cases approaching an alarming 756 million, the multifaceted challenges of Long COVID are undeniable. These challenges span from individual health complications to considerable burdens on worldwide healthcare systems. Our review comprehensively examines the complications of the persistent cardiovascular complications associated with COVID-19. Furthermore, we shed light on emerging therapeutic strategies that promise to manage and possibly mitigate these complications. We also introduce and discuss the profound concerns regarding the potential transgenerational repercussions of SARS-CoV-2, emphasizing the need for a proactive and informed approach to future research and clinical practice. |
| first_indexed | 2024-03-07T18:59:30Z |
| format | Article |
| id | doaj.art-78826c3e18b549c39c9582f2c8652e3e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-07T18:59:30Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-78826c3e18b549c39c9582f2c8652e3e2024-03-01T17:46:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.12685711268571Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVIDRoba Hamed Mostafa0Roba Hamed Mostafa1Ahmed Moustafa2Ahmed Moustafa3Ahmed Moustafa4Systems Genomics Laboratory, American University in Cairo, New Cairo, EgyptBiotechnology Graduate Program, American University in Cairo, New Cairo, EgyptSystems Genomics Laboratory, American University in Cairo, New Cairo, EgyptBiotechnology Graduate Program, American University in Cairo, New Cairo, EgyptDepartment of Biology, American University in Cairo, New Cairo, EgyptSARS-CoV-2, responsible for the global COVID-19 pandemic, has manifested significant cardiovascular implications for the infected population. These cardiovascular repercussions not only linger beyond the initial phase of illness but have also been observed in individuals who remain asymptomatic. This extended and pervasive impact is often called the post-acute COVID-19 syndrome (PACS) or “Long COVID”. With the number of confirmed global cases approaching an alarming 756 million, the multifaceted challenges of Long COVID are undeniable. These challenges span from individual health complications to considerable burdens on worldwide healthcare systems. Our review comprehensively examines the complications of the persistent cardiovascular complications associated with COVID-19. Furthermore, we shed light on emerging therapeutic strategies that promise to manage and possibly mitigate these complications. We also introduce and discuss the profound concerns regarding the potential transgenerational repercussions of SARS-CoV-2, emphasizing the need for a proactive and informed approach to future research and clinical practice.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1268571/fullSARS-CoV-2cardiovascularlong COVIDpost-acute COVID-19 syndrome (PACS)transgenerational inheritance |
| spellingShingle | Roba Hamed Mostafa Roba Hamed Mostafa Ahmed Moustafa Ahmed Moustafa Ahmed Moustafa Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID Frontiers in Cardiovascular Medicine SARS-CoV-2 cardiovascular long COVID post-acute COVID-19 syndrome (PACS) transgenerational inheritance |
| title | Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID |
| title_full | Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID |
| title_fullStr | Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID |
| title_full_unstemmed | Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID |
| title_short | Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID |
| title_sort | beyond acute infection molecular mechanisms underpinning cardiovascular complications in long covid |
| topic | SARS-CoV-2 cardiovascular long COVID post-acute COVID-19 syndrome (PACS) transgenerational inheritance |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1268571/full |
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