Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/10/12/315 |
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| author | Pria N. Ghosh Lola M. Brookes Hannah M. Edwards Matthew C. Fisher Phillip Jervis Dana Kappel Thomas R. Sewell Jennifer M.G. Shelton Emily Skelly Johanna L. Rhodes |
| author_facet | Pria N. Ghosh Lola M. Brookes Hannah M. Edwards Matthew C. Fisher Phillip Jervis Dana Kappel Thomas R. Sewell Jennifer M.G. Shelton Emily Skelly Johanna L. Rhodes |
| author_sort | Pria N. Ghosh |
| collection | DOAJ |
| description | Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future. |
| first_indexed | 2024-03-10T14:29:12Z |
| format | Article |
| id | doaj.art-788271b80ff94950af92af9337c6c2ea |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T14:29:12Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-788271b80ff94950af92af9337c6c2ea2023-11-20T22:43:26ZengMDPI AGLife2075-17292020-11-01101231510.3390/life10120315Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal InfectionsPria N. Ghosh0Lola M. Brookes1Hannah M. Edwards2Matthew C. Fisher3Phillip Jervis4Dana Kappel5Thomas R. Sewell6Jennifer M.G. Shelton7Emily Skelly8Johanna L. Rhodes9Department of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKDepartment of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UKEmerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future.https://www.mdpi.com/2075-1729/10/12/315cross-disciplinaryfungal-omicsemerging fungal pathogen |
| spellingShingle | Pria N. Ghosh Lola M. Brookes Hannah M. Edwards Matthew C. Fisher Phillip Jervis Dana Kappel Thomas R. Sewell Jennifer M.G. Shelton Emily Skelly Johanna L. Rhodes Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections Life cross-disciplinary fungal-omics emerging fungal pathogen |
| title | Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections |
| title_full | Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections |
| title_fullStr | Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections |
| title_full_unstemmed | Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections |
| title_short | Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections |
| title_sort | cross disciplinary genomics approaches to studying emerging fungal infections |
| topic | cross-disciplinary fungal-omics emerging fungal pathogen |
| url | https://www.mdpi.com/2075-1729/10/12/315 |
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