Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces (Candida) glabrata via a novel CRISPR activation system

Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces (Candida) glabrata via a novel CRISPR activation system

ABSTRACTThe overexpression of genes frequently arises in Nakaseomyces (formerly Candida) glabrata via gain-of-function mutations, gene duplication, or aneuploidies, with important consequences on pathogenesis traits and antifungal drug resistance. This highlights the need to develop specific genetic...

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Bibliographic Details
Main Authors: Laetitia Maroc, Hajer Shaker, Rebecca S. Shapiro
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSphere
Subjects:
fungal genetics
Nakaseomyces glabrata
CRISPR
genetic regulation
antifungal drug resistance
stress tolerance
Online Access:https://journals.asm.org/doi/10.1128/msphere.00761-23

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