Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles

Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles

Extracellular vesicles (EVs) mediate critical intercellular communication within healthy tissues, but are also exploited by tumour cells to promote angiogenesis, metastasis, and host immunosuppression under hypoxic stress. We hypothesize that hypoxic tumours synthesize hypoxia-sensitive proteins for...

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Bibliographic Details
Main Authors: Shun Wilford Tse, Chee Fan Tan, Jung Eun Park, JebaMercy Gnanasekaran, Nikhil Gupta, Jee Keem Low, Kheng Wei Yeoh, Wee Joo Chng, Chor Yong Tay, Neil E. McCarthy, Sai Kiang Lim, Siu Kwan Sze
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
extracellular vesicles
hypoxia
tumour microenvironment
epithelial–mesenchymal transition
tumorigenesis
pulsed-SILAC
Online Access:https://www.mdpi.com/2072-6694/12/10/2917

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