Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study
The association between cigarette smoking and the risk of developing malignant glioma (MG) remains unclear. We aimed to evaluate this potential association in a large general population, using a well-established and validated longitudinal nationwide database. Using data from the Korean National Heal...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/5/1343 |
| _version_ | 1797567090224267264 |
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| author | Stephen Ahn Kyung-Do Han Yong-Moon Park Jung Min Bae Sang Uk Kim Sin-Soo Jeun Seung Ho Yang |
| author_facet | Stephen Ahn Kyung-Do Han Yong-Moon Park Jung Min Bae Sang Uk Kim Sin-Soo Jeun Seung Ho Yang |
| author_sort | Stephen Ahn |
| collection | DOAJ |
| description | The association between cigarette smoking and the risk of developing malignant glioma (MG) remains unclear. We aimed to evaluate this potential association in a large general population, using a well-established and validated longitudinal nationwide database. Using data from the Korean National Health Insurance System cohort, 9,811,768 people over 20 years old without any cancer history in 2009 were followed until the end of 2017. We documented 6100 MG cases (ICD-10 code C71) during the median follow-up period of 7.31 years. Current smokers had a higher risk of developing MG (HR = 1.22, CI: 1.13–1.32) compared with never-smokers, after adjusting for confounders. This association was stronger for those who smoked ≥ 20 cigarettes daily (HR = 1.50, CI: 1.36–1.64). Furthermore, having 30 or more pack-years of smoking over the course of one’s lifetime was associated with an increased risk of developing MG in a dose-dependent manner, compared with never-smokers (HR = 1.31, CI: 1.16–1.48 for 30–39 pack-years of smoking; HR = 1.36, CI: 1.17–1.59 for 40–49 pack-years of smoking; HR = 1.68; CI: 1.44–1.95 for ≥ 50 pack-years of smoking). These results suggest that cigarette smoking may be associated with developing MG. Further prospective studies could help elucidate this association. |
| first_indexed | 2024-03-10T19:36:40Z |
| format | Article |
| id | doaj.art-7884acacc61641b69ae629a2a790dedf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:36:40Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7884acacc61641b69ae629a2a790dedf2023-11-20T01:36:17ZengMDPI AGCancers2072-66942020-05-01125134310.3390/cancers12051343Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort StudyStephen Ahn0Kyung-Do Han1Yong-Moon Park2Jung Min Bae3Sang Uk Kim4Sin-Soo Jeun5Seung Ho Yang6Department of Neurosurgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaStatistics and Actuarial Science, Soongsil University, Seoul 06978, KoreaEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USADepartment of Dermatology, St. Vincent’s Hospital College of Medicine, The Catholic University of Korea, Seoul 16247, KoreaMyoungJi St. Mary’s Hospital, Seoul 07417, KoreaDepartment of Neurosurgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Neurosurgery, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, KoreaThe association between cigarette smoking and the risk of developing malignant glioma (MG) remains unclear. We aimed to evaluate this potential association in a large general population, using a well-established and validated longitudinal nationwide database. Using data from the Korean National Health Insurance System cohort, 9,811,768 people over 20 years old without any cancer history in 2009 were followed until the end of 2017. We documented 6100 MG cases (ICD-10 code C71) during the median follow-up period of 7.31 years. Current smokers had a higher risk of developing MG (HR = 1.22, CI: 1.13–1.32) compared with never-smokers, after adjusting for confounders. This association was stronger for those who smoked ≥ 20 cigarettes daily (HR = 1.50, CI: 1.36–1.64). Furthermore, having 30 or more pack-years of smoking over the course of one’s lifetime was associated with an increased risk of developing MG in a dose-dependent manner, compared with never-smokers (HR = 1.31, CI: 1.16–1.48 for 30–39 pack-years of smoking; HR = 1.36, CI: 1.17–1.59 for 40–49 pack-years of smoking; HR = 1.68; CI: 1.44–1.95 for ≥ 50 pack-years of smoking). These results suggest that cigarette smoking may be associated with developing MG. Further prospective studies could help elucidate this association.https://www.mdpi.com/2072-6694/12/5/1343gliomasmokingrisk factorsepidemiologic studiespopulation |
| spellingShingle | Stephen Ahn Kyung-Do Han Yong-Moon Park Jung Min Bae Sang Uk Kim Sin-Soo Jeun Seung Ho Yang Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study Cancers glioma smoking risk factors epidemiologic studies population |
| title | Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study |
| title_full | Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study |
| title_fullStr | Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study |
| title_short | Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study |
| title_sort | cigarette smoking is associated with increased risk of malignant gliomas a nationwide population based cohort study |
| topic | glioma smoking risk factors epidemiologic studies population |
| url | https://www.mdpi.com/2072-6694/12/5/1343 |
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