Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study
Introduction: This prospective cohort study assessed the effects of chronic hypoxaemia due to high-altitude residency on the cerebral tissue oxygenation (CTO) and cerebrovascular reactivity.Methods: Highlanders, born, raised, and currently living above 2,500 m, without cardiopulmonary disease, parti...
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Frontiers Media S.A.
2023-10-01
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| Serija: | Frontiers in Physiology |
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| Online pristup: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1160050/full |
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| author | Matthias C. Luyken Matthias C. Luyken Paula Appenzeller Paula Appenzeller Philipp M. Scheiwiller Philipp M. Scheiwiller Mona Lichtblau Mona Lichtblau Maamed Mademilov Maamed Mademilov Aybermet Muratbekova Aybermet Muratbekova Ulan Sheraliev Ulan Sheraliev Ainura Abdraeva Ainura Abdraeva Nuriddin Marazhapov Nuriddin Marazhapov Talant M. Sooronbaev Talant M. Sooronbaev Silvia Ulrich Silvia Ulrich Konrad E. Bloch Konrad E. Bloch Michael Furian Michael Furian |
| author_facet | Matthias C. Luyken Matthias C. Luyken Paula Appenzeller Paula Appenzeller Philipp M. Scheiwiller Philipp M. Scheiwiller Mona Lichtblau Mona Lichtblau Maamed Mademilov Maamed Mademilov Aybermet Muratbekova Aybermet Muratbekova Ulan Sheraliev Ulan Sheraliev Ainura Abdraeva Ainura Abdraeva Nuriddin Marazhapov Nuriddin Marazhapov Talant M. Sooronbaev Talant M. Sooronbaev Silvia Ulrich Silvia Ulrich Konrad E. Bloch Konrad E. Bloch Michael Furian Michael Furian |
| author_sort | Matthias C. Luyken |
| collection | DOAJ |
| description | Introduction: This prospective cohort study assessed the effects of chronic hypoxaemia due to high-altitude residency on the cerebral tissue oxygenation (CTO) and cerebrovascular reactivity.Methods: Highlanders, born, raised, and currently living above 2,500 m, without cardiopulmonary disease, participated in a prospective cohort study from 2012 until 2017. The measurements were performed at 3,250 m. After 20 min of rest in supine position while breathing ambient air (FiO2 0.21) or oxygen (FiO2 1.0) in random order, guided hyperventilation followed under the corresponding gas mixture. Finger pulse oximetry (SpO2) and cerebral near-infrared spectroscopy assessing CTO and change in cerebral haemoglobin concentration (cHb), a surrogate of cerebral blood volume changes and cerebrovascular reactivity, were applied. Arterial blood gases were obtained during ambient air breathing.Results: Fifty three highlanders, aged 50 ± 2 years, participated in 2017 and 2012. While breathing air in 2017 vs. 2012, PaO2 was reduced, mean ± SE, 7.40 ± 0.13 vs. 7.84 ± 0.13 kPa; heart rate was increased 77 ± 1 vs. 70 ± 1 bpm (p < 0.05) but CTO remained unchanged, 67.2% ± 0.7% vs. 67.4% ± 0.7%. With oxygen, SpO2 and CTO increased similarly in 2017 and 2012, by a mean (95% CI) of 8.3% (7.5–9.1) vs. 8.5% (7.7–9.3) in SpO2, and 5.5% (4.1–7.0) vs. 4.5% (3.0–6.0) in CTO, respectively. Hyperventilation resulted in less reduction of cHb in 2017 vs. 2012, mean difference (95% CI) in change with air 2.0 U/L (0.3–3.6); with oxygen, 2.1 U/L (0.5–3.7).Conclusion: Within 5 years, CTO in highlanders was preserved despite a decreased PaO2. As this was associated with a reduced response of cerebral blood volume to hypocapnia, adaptation of cerebrovascular reactivity might have occurred. |
| first_indexed | 2024-03-11T19:06:21Z |
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| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-11T19:06:21Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-788522f1ef5a4f4ba66e9bae2c0287282023-10-10T07:16:11ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-10-011410.3389/fphys.2023.11600501160050Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort studyMatthias C. Luyken0Matthias C. Luyken1Paula Appenzeller2Paula Appenzeller3Philipp M. Scheiwiller4Philipp M. Scheiwiller5Mona Lichtblau6Mona Lichtblau7Maamed Mademilov8Maamed Mademilov9Aybermet Muratbekova10Aybermet Muratbekova11Ulan Sheraliev12Ulan Sheraliev13Ainura Abdraeva14Ainura Abdraeva15Nuriddin Marazhapov16Nuriddin Marazhapov17Talant M. Sooronbaev18Talant M. Sooronbaev19Silvia Ulrich20Silvia Ulrich21Konrad E. Bloch22Konrad E. Bloch23Michael Furian24Michael Furian25Department of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanDepartment of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanDepartment of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanDepartment of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanNational Centre for Cardiology and Internal Medicine, Bishkek, KyrgyzstanSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanNational Centre for Cardiology and Internal Medicine, Bishkek, KyrgyzstanSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanNational Centre for Cardiology and Internal Medicine, Bishkek, KyrgyzstanSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanNational Centre for Cardiology and Internal Medicine, Bishkek, KyrgyzstanSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanNational Centre for Cardiology and Internal Medicine, Bishkek, KyrgyzstanSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanNational Centre for Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanDepartment of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanDepartment of Respiratory Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss-Kyrgyz High-Altitude Medicine and Research Initiative, Bishkek, KyrgyzstanIntroduction: This prospective cohort study assessed the effects of chronic hypoxaemia due to high-altitude residency on the cerebral tissue oxygenation (CTO) and cerebrovascular reactivity.Methods: Highlanders, born, raised, and currently living above 2,500 m, without cardiopulmonary disease, participated in a prospective cohort study from 2012 until 2017. The measurements were performed at 3,250 m. After 20 min of rest in supine position while breathing ambient air (FiO2 0.21) or oxygen (FiO2 1.0) in random order, guided hyperventilation followed under the corresponding gas mixture. Finger pulse oximetry (SpO2) and cerebral near-infrared spectroscopy assessing CTO and change in cerebral haemoglobin concentration (cHb), a surrogate of cerebral blood volume changes and cerebrovascular reactivity, were applied. Arterial blood gases were obtained during ambient air breathing.Results: Fifty three highlanders, aged 50 ± 2 years, participated in 2017 and 2012. While breathing air in 2017 vs. 2012, PaO2 was reduced, mean ± SE, 7.40 ± 0.13 vs. 7.84 ± 0.13 kPa; heart rate was increased 77 ± 1 vs. 70 ± 1 bpm (p < 0.05) but CTO remained unchanged, 67.2% ± 0.7% vs. 67.4% ± 0.7%. With oxygen, SpO2 and CTO increased similarly in 2017 and 2012, by a mean (95% CI) of 8.3% (7.5–9.1) vs. 8.5% (7.7–9.3) in SpO2, and 5.5% (4.1–7.0) vs. 4.5% (3.0–6.0) in CTO, respectively. Hyperventilation resulted in less reduction of cHb in 2017 vs. 2012, mean difference (95% CI) in change with air 2.0 U/L (0.3–3.6); with oxygen, 2.1 U/L (0.5–3.7).Conclusion: Within 5 years, CTO in highlanders was preserved despite a decreased PaO2. As this was associated with a reduced response of cerebral blood volume to hypocapnia, adaptation of cerebrovascular reactivity might have occurred.https://www.frontiersin.org/articles/10.3389/fphys.2023.1160050/fullaltitudehighlandersnear-infrared spectroscopycerebral oxygenationhyperoxiahypobaric hypoxia |
| spellingShingle | Matthias C. Luyken Matthias C. Luyken Paula Appenzeller Paula Appenzeller Philipp M. Scheiwiller Philipp M. Scheiwiller Mona Lichtblau Mona Lichtblau Maamed Mademilov Maamed Mademilov Aybermet Muratbekova Aybermet Muratbekova Ulan Sheraliev Ulan Sheraliev Ainura Abdraeva Ainura Abdraeva Nuriddin Marazhapov Nuriddin Marazhapov Talant M. Sooronbaev Talant M. Sooronbaev Silvia Ulrich Silvia Ulrich Konrad E. Bloch Konrad E. Bloch Michael Furian Michael Furian Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study Frontiers in Physiology altitude highlanders near-infrared spectroscopy cerebral oxygenation hyperoxia hypobaric hypoxia |
| title | Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study |
| title_full | Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study |
| title_fullStr | Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study |
| title_full_unstemmed | Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study |
| title_short | Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study |
| title_sort | time course of cerebral oxygenation and cerebrovascular reactivity in kyrgyz highlanders a five year prospective cohort study |
| topic | altitude highlanders near-infrared spectroscopy cerebral oxygenation hyperoxia hypobaric hypoxia |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1160050/full |
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