Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor?
Abstract Background Air pollution is a key public health factor with the capacity to induce diseases. The risk of ischemia heart disease (IHD) in those suffering from systemic lupus erythematosus (SLE) from air pollution exposure is ambiguous. This study aimed to: (1) determine the hazard ratio (HR)...
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| Format: | Article |
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BMC
2023-06-01
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| Series: | BMC Rheumatology |
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| Online Access: | https://doi.org/10.1186/s41927-023-00337-8 |
| _version_ | 1797806441632890880 |
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| author | Pei-Yun Chen Yu-Tse Tsan Chao-Tung Yang Yun-Mei Lee Li-Li Chen Wen-Chao Ho Shu-Hua Lu |
| author_facet | Pei-Yun Chen Yu-Tse Tsan Chao-Tung Yang Yun-Mei Lee Li-Li Chen Wen-Chao Ho Shu-Hua Lu |
| author_sort | Pei-Yun Chen |
| collection | DOAJ |
| description | Abstract Background Air pollution is a key public health factor with the capacity to induce diseases. The risk of ischemia heart disease (IHD) in those suffering from systemic lupus erythematosus (SLE) from air pollution exposure is ambiguous. This study aimed to: (1) determine the hazard ratio (HR) of IHD after the first-diagnosed SLE and (2) examine the effects of air pollution exposure on IHD in SLE for 12 years. Methods This is a retrospective cohort study. Taiwan’s National Health Insurance Research Database and Taiwan Air Quality Monitoring data were used in the study. Cases first diagnosed with SLE in 2006 cases without IHD were recruited as the SLE group. We randomly selected an additional sex-matched non-SLE cohort, four times the size of the SLE cohort, as the control group. Air pollution indices by residence city per period were calculated as the exposure. Life tables and Cox proportional risk models of time-dependent covariance were used in the research. Results This study identified patients for the SLE group (n = 4,842) and the control group (n = 19,368) in 2006. By the end of 2018, the risk of IHD was significantly higher in the SLE group than in the control group, and risks peaked between the 6th and 9th year. The HR of incidence IHD in the SLE group was 2.42 times that of the control group. Significant correlations with risk of developing IHD were noted for sex, age, CO, NO2, PM10, and PM2.5, of which PM10 exposure had the highest risk of IHD incidence. Conclusions Subjects with SLE were at a higher risk of IHD, especially those in the 6th to 9th year after SLE diagnosis. The advanced cardiac health examinations and health education plan should be recommended for SLE patients before the 6th year after SLE diagnosed. |
| first_indexed | 2024-03-13T06:07:22Z |
| format | Article |
| id | doaj.art-788602379dd5453db286dfda4c9d88fb |
| institution | Directory Open Access Journal |
| issn | 2520-1026 |
| language | English |
| last_indexed | 2024-03-13T06:07:22Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Rheumatology |
| spelling | doaj.art-788602379dd5453db286dfda4c9d88fb2023-06-11T11:28:13ZengBMCBMC Rheumatology2520-10262023-06-01711910.1186/s41927-023-00337-8Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor?Pei-Yun Chen0Yu-Tse Tsan1Chao-Tung Yang2Yun-Mei Lee3Li-Li Chen4Wen-Chao Ho5Shu-Hua Lu6Departmant of public Health, China Medical UniversityDivision of Occupational Medicine, Department of Emergency Medicine, Taichung Veterans General HospitalDepartment of Computer Science, Tunghai UniversityDepartment of Nursing, Cardinal Tien Junior College of Healthcare and ManagementSchool of Nursing, China Medical UniversityDepartmant of public Health, China Medical UniversitySchool of Nursing, China Medical UniversityAbstract Background Air pollution is a key public health factor with the capacity to induce diseases. The risk of ischemia heart disease (IHD) in those suffering from systemic lupus erythematosus (SLE) from air pollution exposure is ambiguous. This study aimed to: (1) determine the hazard ratio (HR) of IHD after the first-diagnosed SLE and (2) examine the effects of air pollution exposure on IHD in SLE for 12 years. Methods This is a retrospective cohort study. Taiwan’s National Health Insurance Research Database and Taiwan Air Quality Monitoring data were used in the study. Cases first diagnosed with SLE in 2006 cases without IHD were recruited as the SLE group. We randomly selected an additional sex-matched non-SLE cohort, four times the size of the SLE cohort, as the control group. Air pollution indices by residence city per period were calculated as the exposure. Life tables and Cox proportional risk models of time-dependent covariance were used in the research. Results This study identified patients for the SLE group (n = 4,842) and the control group (n = 19,368) in 2006. By the end of 2018, the risk of IHD was significantly higher in the SLE group than in the control group, and risks peaked between the 6th and 9th year. The HR of incidence IHD in the SLE group was 2.42 times that of the control group. Significant correlations with risk of developing IHD were noted for sex, age, CO, NO2, PM10, and PM2.5, of which PM10 exposure had the highest risk of IHD incidence. Conclusions Subjects with SLE were at a higher risk of IHD, especially those in the 6th to 9th year after SLE diagnosis. The advanced cardiac health examinations and health education plan should be recommended for SLE patients before the 6th year after SLE diagnosed.https://doi.org/10.1186/s41927-023-00337-8Ischemic heart diseaseSystemic lupus erythematosusAir pollutionHazard |
| spellingShingle | Pei-Yun Chen Yu-Tse Tsan Chao-Tung Yang Yun-Mei Lee Li-Li Chen Wen-Chao Ho Shu-Hua Lu Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor? BMC Rheumatology Ischemic heart disease Systemic lupus erythematosus Air pollution Hazard |
| title | Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor? |
| title_full | Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor? |
| title_fullStr | Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor? |
| title_full_unstemmed | Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor? |
| title_short | Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor? |
| title_sort | prediction of risk of ischemic heart disease in first diagnosed systemic lupus erythematosus patients in taiwan is air pollution exposure a risk factor |
| topic | Ischemic heart disease Systemic lupus erythematosus Air pollution Hazard |
| url | https://doi.org/10.1186/s41927-023-00337-8 |
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