Celiac disease in children: Increasing prevalence and changing clinical presentations
Background Celiac disease (CD) is a chronic autoimmune enteropathy. It results from genetic predisposition and exposure to gluten-containing food. The prevalence and presentation of CD vary among populations. Purpose This study aimed to describe the prevalence and clinical characteristics of CD in c...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2021-06-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2020-00304.pdf |
| _version_ | 1818735125467234304 |
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| author | Hasan M. Isa Eman Farid Jaafar J. Makhlooq Afaf M. Mohamed Jumana G. Al-Arayedh Fawzeya A. Alahmed Shima Medani |
| author_facet | Hasan M. Isa Eman Farid Jaafar J. Makhlooq Afaf M. Mohamed Jumana G. Al-Arayedh Fawzeya A. Alahmed Shima Medani |
| author_sort | Hasan M. Isa |
| collection | DOAJ |
| description | Background Celiac disease (CD) is a chronic autoimmune enteropathy. It results from genetic predisposition and exposure to gluten-containing food. The prevalence and presentation of CD vary among populations. Purpose This study aimed to describe the prevalence and clinical characteristics of CD in children in Bahrain. Methods We retrospectively reviewed the medical records of children diagnosed with CD in the pediatric department, Salmaniya Medical Complex, Bahrain, in 1988–2018. Their clinical, biochemical, serological, and histopathological findings were documented. Adherence to the recommended gluten-free diet (GFD) was assessed. Results Of 86 patients with CD, 67 were included. The CD prevalence was 0.02%. A significant increase in prevalence in the last decade was observed (P<0.0001). Thirty-eight patients (56.7%) were males. The median (interquartile range) age at presentation was 4.45 (1.5—7.3) years. A family history of CD was positive in 13 out of 43 patients (30.2%). Pallor and failure to thrive were the most common presentations. The most frequent associated disease was iron-deficiency anemia in 23 patients (69.7%). Positive serology was found in 32 of 45 patients (71.1%). Marsh-Oberhuber type III was found in 16 of 35 patients (45.7%). Seropositive patients were significantly older (P=0.025) and had more severe duodenal histology (P=0.002). Adherence to GFD was poor in 27 patients (64.3%). Conclusion This study revealed a significant increase in CD prevalence over the last decade. Atypical presentations were frequent. Most patients had poor adherence to GFD. |
| first_indexed | 2024-12-18T00:16:17Z |
| format | Article |
| id | doaj.art-78880878c7474c089c19c6afc3f13c0e |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-18T00:16:17Z |
| publishDate | 2021-06-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-78880878c7474c089c19c6afc3f13c0e2022-12-21T21:27:30ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482021-06-0164630130910.3345/cep.2020.0030420125555372Celiac disease in children: Increasing prevalence and changing clinical presentationsHasan M. Isa0Eman Farid1Jaafar J. Makhlooq2Afaf M. Mohamed3Jumana G. Al-Arayedh4Fawzeya A. Alahmed5Shima Medani6 Pediatric Department, Salmaniya Medical Complex, Arabian Gulf University, Manama, Bahrain Pathology Department, Salmaniya Medical Complex, Arabian Gulf University, Manama, Bahrain Pediatric Department, Salmaniya Medical Complex, Manama, Bahrain Puplic Health Department, Ministry of Health, Manama, Bahrain Pediatric Department, Salmaniya Medical Complex, Manama, Bahrain Pediatric Department, Salmaniya Medical Complex, Manama, Bahrain Pathology Department, Salmaniya Medical Complex, Manama, BahrainBackground Celiac disease (CD) is a chronic autoimmune enteropathy. It results from genetic predisposition and exposure to gluten-containing food. The prevalence and presentation of CD vary among populations. Purpose This study aimed to describe the prevalence and clinical characteristics of CD in children in Bahrain. Methods We retrospectively reviewed the medical records of children diagnosed with CD in the pediatric department, Salmaniya Medical Complex, Bahrain, in 1988–2018. Their clinical, biochemical, serological, and histopathological findings were documented. Adherence to the recommended gluten-free diet (GFD) was assessed. Results Of 86 patients with CD, 67 were included. The CD prevalence was 0.02%. A significant increase in prevalence in the last decade was observed (P<0.0001). Thirty-eight patients (56.7%) were males. The median (interquartile range) age at presentation was 4.45 (1.5—7.3) years. A family history of CD was positive in 13 out of 43 patients (30.2%). Pallor and failure to thrive were the most common presentations. The most frequent associated disease was iron-deficiency anemia in 23 patients (69.7%). Positive serology was found in 32 of 45 patients (71.1%). Marsh-Oberhuber type III was found in 16 of 35 patients (45.7%). Seropositive patients were significantly older (P=0.025) and had more severe duodenal histology (P=0.002). Adherence to GFD was poor in 27 patients (64.3%). Conclusion This study revealed a significant increase in CD prevalence over the last decade. Atypical presentations were frequent. Most patients had poor adherence to GFD.http://www.e-cep.org/upload/pdf/cep-2020-00304.pdfceliac diseasechildprevalenceclinical presentationbahrain |
| spellingShingle | Hasan M. Isa Eman Farid Jaafar J. Makhlooq Afaf M. Mohamed Jumana G. Al-Arayedh Fawzeya A. Alahmed Shima Medani Celiac disease in children: Increasing prevalence and changing clinical presentations Clinical and Experimental Pediatrics celiac disease child prevalence clinical presentation bahrain |
| title | Celiac disease in children: Increasing prevalence and changing clinical presentations |
| title_full | Celiac disease in children: Increasing prevalence and changing clinical presentations |
| title_fullStr | Celiac disease in children: Increasing prevalence and changing clinical presentations |
| title_full_unstemmed | Celiac disease in children: Increasing prevalence and changing clinical presentations |
| title_short | Celiac disease in children: Increasing prevalence and changing clinical presentations |
| title_sort | celiac disease in children increasing prevalence and changing clinical presentations |
| topic | celiac disease child prevalence clinical presentation bahrain |
| url | http://www.e-cep.org/upload/pdf/cep-2020-00304.pdf |
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