Structural Model for Tubulin Recognition and Deformation by Kinesin-13 Microtubule Depolymerases

Structural Model for Tubulin Recognition and Deformation by Kinesin-13 Microtubule Depolymerases

To elucidate the structural basis of the mechanism of microtubule depolymerization by kinesin-13s, we analyzed complexes of tubulin and the Drosophila melanogaster kinesin-13 KLP10A by electron microscopy (EM) and fluorescence polarization microscopy. We report a nanometer-resolution (1.1 nm) cryo-E...

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Bibliographic Details
Main Authors: Ana B. Asenjo, Chandrima Chatterjee, Dongyan Tan, Vania DePaoli, William J. Rice, Ruben Diaz-Avalos, Mariena Silvestry, Hernando Sosa
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713000545

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