Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer
Pancreatic ductal adenocarcinoma, an extremely aggressive cancer, has high metastatic potential. Cutaneous metastasis is very uncommon, representing only <10% of all cases, presenting mostly around the umbilical region. Non-umbilical metastasis is even rarer, and the significance remains unknown....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-06-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709620931667 |
| _version_ | 1818419608931008512 |
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| author | Preethi Ramachandran MD Lakshmi Boyapati MD Gardith Joseph MD |
| author_facet | Preethi Ramachandran MD Lakshmi Boyapati MD Gardith Joseph MD |
| author_sort | Preethi Ramachandran MD |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma, an extremely aggressive cancer, has high metastatic potential. Cutaneous metastasis is very uncommon, representing only <10% of all cases, presenting mostly around the umbilical region. Non-umbilical metastasis is even rarer, and the significance remains unknown. In this article, we describe a case of a 76-year-old gentleman who initially presented with an asymptomatic scalp lesion, which on biopsy revealed metastatic adenocarcinoma of pancreatic origin. Detailed workup revealed extremely high tumor burden with metastases involving muscles, subcutaneous tissues, bone, lung, spleen, liver, and colon. Cutaneous involvement in pancreatic cancer represents poor survival with widespread dissemination of the disease. The involvement of some sites and not others and the extreme degree of aggressiveness might reflect subgroups of this cancer with different molecular biology. Identifying these groups may have utility in determining prognosis and stratifying treatment for patients. This will hopefully translate into better diagnostic tests and therapies in the near future. |
| first_indexed | 2024-12-14T12:41:17Z |
| format | Article |
| id | doaj.art-78889e0201664802859f31c632b2c04e |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-14T12:41:17Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-78889e0201664802859f31c632b2c04e2022-12-21T23:00:55ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962020-06-01810.1177/2324709620931667Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic CancerPreethi Ramachandran MD0Lakshmi Boyapati MD1Gardith Joseph MD2Brookdale University Hospitals and Medical Center, Brooklyn, NY, USABrookdale University Hospitals and Medical Center, Brooklyn, NY, USABrookdale University Hospitals and Medical Center, Brooklyn, NY, USAPancreatic ductal adenocarcinoma, an extremely aggressive cancer, has high metastatic potential. Cutaneous metastasis is very uncommon, representing only <10% of all cases, presenting mostly around the umbilical region. Non-umbilical metastasis is even rarer, and the significance remains unknown. In this article, we describe a case of a 76-year-old gentleman who initially presented with an asymptomatic scalp lesion, which on biopsy revealed metastatic adenocarcinoma of pancreatic origin. Detailed workup revealed extremely high tumor burden with metastases involving muscles, subcutaneous tissues, bone, lung, spleen, liver, and colon. Cutaneous involvement in pancreatic cancer represents poor survival with widespread dissemination of the disease. The involvement of some sites and not others and the extreme degree of aggressiveness might reflect subgroups of this cancer with different molecular biology. Identifying these groups may have utility in determining prognosis and stratifying treatment for patients. This will hopefully translate into better diagnostic tests and therapies in the near future.https://doi.org/10.1177/2324709620931667 |
| spellingShingle | Preethi Ramachandran MD Lakshmi Boyapati MD Gardith Joseph MD Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer Journal of Investigative Medicine High Impact Case Reports |
| title | Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer |
| title_full | Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer |
| title_fullStr | Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer |
| title_full_unstemmed | Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer |
| title_short | Scalp Metastasis as the First Presentation of an Underlying Aggressive Pancreatic Cancer |
| title_sort | scalp metastasis as the first presentation of an underlying aggressive pancreatic cancer |
| url | https://doi.org/10.1177/2324709620931667 |
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