LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND
Objective: To study the content of superoxide dismutase (SOD) and malonic dialdehyde (MDA) in the blood of children by the influence of heightened radiation background. Methods: The levels of MDA and SOD in the blood were determined in 20 newborns and in 60 to 3-5 years old children living in the...
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| Format: | Article |
| Language: | English |
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Avicenna Tajik State Medical University
2019-03-01
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| Series: | Паёми Сино |
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| Online Access: | https://doi.org/10.25005/2074-0581-2019-21-1-71-76 |
| _version_ | 1797797539743793152 |
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| author | Z.A. BADALOVA J.S. DODKHOEV A.M. SABUROVA |
| author_facet | Z.A. BADALOVA J.S. DODKHOEV A.M. SABUROVA |
| author_sort | Z.A. BADALOVA |
| collection | DOAJ |
| description | Objective: To study the content of superoxide dismutase (SOD) and malonic dialdehyde (MDA) in the blood of children by the influence of heightened radiation background.
Methods: The levels of MDA and SOD in the blood were determined in 20 newborns and in 60 to 3-5 years old children living in the area of high radiation background. The control group included 80 children and newborns living in areas with a natural radiation background. The content of MDA was determined by the method of I.D. Stalnaya, and the level of SOD – by the method of reduction of nitro-blue tetrazole in serum.
Results: Levels of MDA in children living in conditions with a natural radiation background, were: newborns – 0.065±0.003 μmol/l; 3 years old children – 0.073±0.003 μmol/l; children 4 years old – 0.065±0.003 μmol/l; children 5 years old – 0.060±0.002 μmol/l. At the same time, in children living in conditions of heightened radiation background, the level of MDA was higher, with the greatest level among newborns – 0.879±0.025 μmol/l. In children 3, 4 and 5 years, this values were 0.301±0.025; 0.338±0.027 and 0.671±0.049 μmol/l, accordingly. The content of SOD in children living in conditions with a normal natural radiation background was as follows: newborns – 12.7±0.2 c. u./l; children 3 years old – 13.1±0.1 c. u./l; children 4 years old – 13.4±0.1 c. u./l; children 5 years old – 13.1±0.1 c. u./l. At the same time, in children living in conditions of heightened radiation background, considerably low levels of SOD were detected: newborns – 11.5±0.2 c. u./l; children 3 years old – 11.7±0.1 c. u./l; children 4 years old – 11.5±0.1 c. u./l; children 5 years old – 11.5±0.1 c. u./l.
Conclusion: The results of conducted research revealed the presence of oxidative stress and imbalance of the pro- and antioxidant systems in children living in conditions of heightened radiation background |
| first_indexed | 2024-03-13T03:49:53Z |
| format | Article |
| id | doaj.art-7888e63a27b0486ca1da3ed1258e5f77 |
| institution | Directory Open Access Journal |
| issn | 2074-0581 2959-6327 |
| language | English |
| last_indexed | 2024-03-13T03:49:53Z |
| publishDate | 2019-03-01 |
| publisher | Avicenna Tajik State Medical University |
| record_format | Article |
| series | Паёми Сино |
| spelling | doaj.art-7888e63a27b0486ca1da3ed1258e5f772023-06-22T18:01:06ZengAvicenna Tajik State Medical UniversityПаёми Сино2074-05812959-63272019-03-01211717610.25005/2074-0581-2019-21-1-71-76LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUNDZ.A. BADALOVA0J.S. DODKHOEV1A.M. SABUROVA2Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of TajikistanDepartment of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of TajikistanDepartment of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of TajikistanObjective: To study the content of superoxide dismutase (SOD) and malonic dialdehyde (MDA) in the blood of children by the influence of heightened radiation background. Methods: The levels of MDA and SOD in the blood were determined in 20 newborns and in 60 to 3-5 years old children living in the area of high radiation background. The control group included 80 children and newborns living in areas with a natural radiation background. The content of MDA was determined by the method of I.D. Stalnaya, and the level of SOD – by the method of reduction of nitro-blue tetrazole in serum. Results: Levels of MDA in children living in conditions with a natural radiation background, were: newborns – 0.065±0.003 μmol/l; 3 years old children – 0.073±0.003 μmol/l; children 4 years old – 0.065±0.003 μmol/l; children 5 years old – 0.060±0.002 μmol/l. At the same time, in children living in conditions of heightened radiation background, the level of MDA was higher, with the greatest level among newborns – 0.879±0.025 μmol/l. In children 3, 4 and 5 years, this values were 0.301±0.025; 0.338±0.027 and 0.671±0.049 μmol/l, accordingly. The content of SOD in children living in conditions with a normal natural radiation background was as follows: newborns – 12.7±0.2 c. u./l; children 3 years old – 13.1±0.1 c. u./l; children 4 years old – 13.4±0.1 c. u./l; children 5 years old – 13.1±0.1 c. u./l. At the same time, in children living in conditions of heightened radiation background, considerably low levels of SOD were detected: newborns – 11.5±0.2 c. u./l; children 3 years old – 11.7±0.1 c. u./l; children 4 years old – 11.5±0.1 c. u./l; children 5 years old – 11.5±0.1 c. u./l. Conclusion: The results of conducted research revealed the presence of oxidative stress and imbalance of the pro- and antioxidant systems in children living in conditions of heightened radiation backgroundhttps://doi.org/10.25005/2074-0581-2019-21-1-71-76superoxide dismutasemalonic dialdehyderadiationchildren. |
| spellingShingle | Z.A. BADALOVA J.S. DODKHOEV A.M. SABUROVA LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND Паёми Сино superoxide dismutase malonic dialdehyde radiation children. |
| title | LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND |
| title_full | LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND |
| title_fullStr | LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND |
| title_full_unstemmed | LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND |
| title_short | LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND |
| title_sort | levels of malonic dialdehyde and superoxide dismutase in children from a zone with heightened radiation background |
| topic | superoxide dismutase malonic dialdehyde radiation children. |
| url | https://doi.org/10.25005/2074-0581-2019-21-1-71-76 |
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