Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons
Interferons (IFNs) are a group of cellular proteins with critical roles in the regulation of immune responses in the course of microbial infections. Moreover, expressions of IFNs are dysregulated in autoimmune disorders. IFNs are also a part of immune responses in malignant conditions. The expressio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.877243/full |
| _version_ | 1818010783891587072 |
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| author | Soudeh Ghafouri-Fard Yadollah Poornajaf Farzaneh Dashti Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Elena Jamali Elena Jamali |
| author_facet | Soudeh Ghafouri-Fard Yadollah Poornajaf Farzaneh Dashti Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Elena Jamali Elena Jamali |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Interferons (IFNs) are a group of cellular proteins with critical roles in the regulation of immune responses in the course of microbial infections. Moreover, expressions of IFNs are dysregulated in autoimmune disorders. IFNs are also a part of immune responses in malignant conditions. The expression of these proteins and activities of related signaling can be influenced by a number of non-coding RNAs. IFN regulatory factors (IRFs) are the most investigated molecules in the field of effects of non-coding RNAs on IFN signaling. These interactions have been best assessed in the context of cancer, revealing the importance of immune function in the pathoetiology of cancer. In addition, IFN-related non-coding RNAs may contribute to the pathogenesis of neuropsychiatric conditions, systemic sclerosis, Newcastle disease, Sjögren’s syndrome, traumatic brain injury, lupus nephritis, systemic lupus erythematosus, diabetes mellitus, and myocardial ischemia/reperfusion injury. In the current review, we describe the role of microRNAs and long non-coding RNAs in the regulation of IFN signaling. |
| first_indexed | 2024-04-14T05:59:53Z |
| format | Article |
| id | doaj.art-788935505c914fdb97915599614dec9f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T05:59:53Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-788935505c914fdb97915599614dec9f2022-12-22T02:08:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.877243877243Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I InterferonsSoudeh Ghafouri-Fard0Yadollah Poornajaf1Farzaneh Dashti2Bashdar Mahmud Hussen3Bashdar Mahmud Hussen4Mohammad Taheri5Mohammad Taheri6Elena Jamali7Elena Jamali8Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Medicine, Birjand University of Medical Sciences, Birjand, IranFaculty of Medicine, Birjand University of Medical Sciences, Birjand, IranDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqCenter of Research and Strategic Studies, Lebanese French University, Erbil, IraqUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranInstitute of Human Genetics, Jena University Hospital, Jena, GermanySkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInterferons (IFNs) are a group of cellular proteins with critical roles in the regulation of immune responses in the course of microbial infections. Moreover, expressions of IFNs are dysregulated in autoimmune disorders. IFNs are also a part of immune responses in malignant conditions. The expression of these proteins and activities of related signaling can be influenced by a number of non-coding RNAs. IFN regulatory factors (IRFs) are the most investigated molecules in the field of effects of non-coding RNAs on IFN signaling. These interactions have been best assessed in the context of cancer, revealing the importance of immune function in the pathoetiology of cancer. In addition, IFN-related non-coding RNAs may contribute to the pathogenesis of neuropsychiatric conditions, systemic sclerosis, Newcastle disease, Sjögren’s syndrome, traumatic brain injury, lupus nephritis, systemic lupus erythematosus, diabetes mellitus, and myocardial ischemia/reperfusion injury. In the current review, we describe the role of microRNAs and long non-coding RNAs in the regulation of IFN signaling.https://www.frontiersin.org/articles/10.3389/fimmu.2022.877243/fulllncRNAmiRNAinterferonexpressionbiomarker |
| spellingShingle | Soudeh Ghafouri-Fard Yadollah Poornajaf Farzaneh Dashti Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Elena Jamali Elena Jamali Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons Frontiers in Immunology lncRNA miRNA interferon expression biomarker |
| title | Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons |
| title_full | Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons |
| title_fullStr | Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons |
| title_full_unstemmed | Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons |
| title_short | Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons |
| title_sort | interaction between non coding rnas and interferons with an especial focus on type i interferons |
| topic | lncRNA miRNA interferon expression biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.877243/full |
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