Cellular origin of the viral capsid-like bacterial microcompartments
Abstract ᅟ Bacterial microcompartments (BMC) are proteinaceous organelles that structurally resemble viral capsids, but encapsulate enzymes that perform various specialized biochemical reactions in the cell cytoplasm. The BMC are constructed from two major shell proteins, BMC-H and BMC-P, which form...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Biology Direct |
| Online Access: | http://link.springer.com/article/10.1186/s13062-017-0197-y |
| _version_ | 1828484934127321088 |
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| author | Mart Krupovic Eugene V. Koonin |
| author_facet | Mart Krupovic Eugene V. Koonin |
| author_sort | Mart Krupovic |
| collection | DOAJ |
| description | Abstract ᅟ Bacterial microcompartments (BMC) are proteinaceous organelles that structurally resemble viral capsids, but encapsulate enzymes that perform various specialized biochemical reactions in the cell cytoplasm. The BMC are constructed from two major shell proteins, BMC-H and BMC-P, which form the facets and vertices of the icosahedral assembly, and are functionally equivalent to the major and minor capsid proteins of viruses, respectively. This equivalence notwithstanding, neither of the BMC proteins displays structural similarity to known capsid proteins, rendering the origins of the BMC enigmatic. Here, using structural and sequence comparisons, we show that both BMC-H and BMC-P, most likely, were exapted from bona fide cellular proteins, namely, PII signaling protein and OB-fold domain-containing protein, respectively. This finding is in line with the hypothesis that many major viral structural proteins have been recruited from cellular proteomes. Reviewers This article was reviewed by Igor Zhulin, Jeremy Selengut and Narayanaswamy Srinivasan. For complete reviews, see the Reviewers’ reports section. |
| first_indexed | 2024-12-11T09:04:27Z |
| format | Article |
| id | doaj.art-788adc9222674552af09fd35ad5066b5 |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-12-11T09:04:27Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-788adc9222674552af09fd35ad5066b52022-12-22T01:13:40ZengBMCBiology Direct1745-61502017-11-011211610.1186/s13062-017-0197-yCellular origin of the viral capsid-like bacterial microcompartmentsMart Krupovic0Eugene V. Koonin1Department of Microbiology, Institut PasteurNational Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthAbstract ᅟ Bacterial microcompartments (BMC) are proteinaceous organelles that structurally resemble viral capsids, but encapsulate enzymes that perform various specialized biochemical reactions in the cell cytoplasm. The BMC are constructed from two major shell proteins, BMC-H and BMC-P, which form the facets and vertices of the icosahedral assembly, and are functionally equivalent to the major and minor capsid proteins of viruses, respectively. This equivalence notwithstanding, neither of the BMC proteins displays structural similarity to known capsid proteins, rendering the origins of the BMC enigmatic. Here, using structural and sequence comparisons, we show that both BMC-H and BMC-P, most likely, were exapted from bona fide cellular proteins, namely, PII signaling protein and OB-fold domain-containing protein, respectively. This finding is in line with the hypothesis that many major viral structural proteins have been recruited from cellular proteomes. Reviewers This article was reviewed by Igor Zhulin, Jeremy Selengut and Narayanaswamy Srinivasan. For complete reviews, see the Reviewers’ reports section.http://link.springer.com/article/10.1186/s13062-017-0197-y |
| spellingShingle | Mart Krupovic Eugene V. Koonin Cellular origin of the viral capsid-like bacterial microcompartments Biology Direct |
| title | Cellular origin of the viral capsid-like bacterial microcompartments |
| title_full | Cellular origin of the viral capsid-like bacterial microcompartments |
| title_fullStr | Cellular origin of the viral capsid-like bacterial microcompartments |
| title_full_unstemmed | Cellular origin of the viral capsid-like bacterial microcompartments |
| title_short | Cellular origin of the viral capsid-like bacterial microcompartments |
| title_sort | cellular origin of the viral capsid like bacterial microcompartments |
| url | http://link.springer.com/article/10.1186/s13062-017-0197-y |
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