Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey
<i>Background and objectives:</i> Urinary tract infections (UTIs) are the third most common infections in humans, representing a significant factor of morbidity, both among outpatients and inpatients. The pathogenic role of <i>Citrobacter</i>, <i>Enterobacter</i>,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/6/285 |
| _version_ | 1797721708621201408 |
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| author | Márió Gajdács Edit Urbán |
| author_facet | Márió Gajdács Edit Urbán |
| author_sort | Márió Gajdács |
| collection | DOAJ |
| description | <i>Background and objectives:</i> Urinary tract infections (UTIs) are the third most common infections in humans, representing a significant factor of morbidity, both among outpatients and inpatients. The pathogenic role of <i>Citrobacter</i>, <i>Enterobacter</i>, and <i>Serratia</i> species (CES bacteria) has been described in UTIs. CES bacteria present a therapeutic challenge due to the various intrinsic and acquired resistance mechanisms they possess. <i>Materials and Methods:</i> The aim of this study was to assess and compare the resistance trends and epidemiology of CES pathogens in UTIs (RECESUTI) in inpatients and outpatients during a 10-year study period. To evaluate the resistance trends of isolated strains, several antibiotics were chosen as indicator drugs based on local utilization data. 578 CES isolates were obtained from inpatients and 554 from outpatients, representing 2.57 ± 0.41% of all positive urine samples for outpatients and 3.02 ± 0.40% for inpatients. <i>E. cloacae</i> was the most prevalent species. <i>Results:</i> The ratio of resistant strains to most of the indicator drugs was higher in the inpatient group and lower in the second half of the study period. ESBL-producing isolates were detected in 0−9.75% from outpatient and 0−29.09% from inpatient samples. <i>Conclusions:</i> Resistance developments of CES bacteria, coupled with their intrinsic non-susceptibility to several antibiotics, severely limits the number of therapeutic alternatives, especially for outpatients. |
| first_indexed | 2024-03-12T09:37:10Z |
| format | Article |
| id | doaj.art-7890531febc446a7905d29e2f958e1a5 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:37:10Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-7890531febc446a7905d29e2f958e1a52023-09-02T13:32:05ZengMDPI AGMedicina1010-660X2019-06-0155628510.3390/medicina55060285medicina55060285Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year SurveyMárió Gajdács0Edit Urbán1Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6., 6720 Szeged, HungaryInstitute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis utca 6., 6725 Szeged, Hungary<i>Background and objectives:</i> Urinary tract infections (UTIs) are the third most common infections in humans, representing a significant factor of morbidity, both among outpatients and inpatients. The pathogenic role of <i>Citrobacter</i>, <i>Enterobacter</i>, and <i>Serratia</i> species (CES bacteria) has been described in UTIs. CES bacteria present a therapeutic challenge due to the various intrinsic and acquired resistance mechanisms they possess. <i>Materials and Methods:</i> The aim of this study was to assess and compare the resistance trends and epidemiology of CES pathogens in UTIs (RECESUTI) in inpatients and outpatients during a 10-year study period. To evaluate the resistance trends of isolated strains, several antibiotics were chosen as indicator drugs based on local utilization data. 578 CES isolates were obtained from inpatients and 554 from outpatients, representing 2.57 ± 0.41% of all positive urine samples for outpatients and 3.02 ± 0.40% for inpatients. <i>E. cloacae</i> was the most prevalent species. <i>Results:</i> The ratio of resistant strains to most of the indicator drugs was higher in the inpatient group and lower in the second half of the study period. ESBL-producing isolates were detected in 0−9.75% from outpatient and 0−29.09% from inpatient samples. <i>Conclusions:</i> Resistance developments of CES bacteria, coupled with their intrinsic non-susceptibility to several antibiotics, severely limits the number of therapeutic alternatives, especially for outpatients.https://www.mdpi.com/1010-660X/55/6/285urinary tract infectionUTIantibioticresistanceindicatorepidemiologyfosfomycinESBL<i>Citrobacter</i><i>Enterobacter</i><i>Serratia</i> |
| spellingShingle | Márió Gajdács Edit Urbán Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey Medicina urinary tract infection UTI antibiotic resistance indicator epidemiology fosfomycin ESBL <i>Citrobacter</i> <i>Enterobacter</i> <i>Serratia</i> |
| title | Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey |
| title_full | Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey |
| title_fullStr | Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey |
| title_full_unstemmed | Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey |
| title_short | Resistance Trends and Epidemiology of <i>Citrobacter</i>-<i>Enterobacter</i>-<i>Serratia</i> in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey |
| title_sort | resistance trends and epidemiology of i citrobacter i i enterobacter i i serratia i in urinary tract infections of inpatients and outpatients recesuti a 10 year survey |
| topic | urinary tract infection UTI antibiotic resistance indicator epidemiology fosfomycin ESBL <i>Citrobacter</i> <i>Enterobacter</i> <i>Serratia</i> |
| url | https://www.mdpi.com/1010-660X/55/6/285 |
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