Does Xpert® MTB/RIF assay give rifampicin resistance results without identified mutation? Review of cases from Addis Ababa, Ethiopia

Does Xpert® MTB/RIF assay give rifampicin resistance results without identified mutation? Review of cases from Addis Ababa, Ethiopia

Abstract Background Xpert® MTB/RIF assay is currently used in Ethiopia for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and mutations that confer Rifampicin resistance. Rifampicin resistance is determined based on any mutation in the 81 bp of rpoB gene using five overlapping probes repres...

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Bibliographic Details
Main Authors: Ayinalem Alemu, Mengistu Tadesse, Getachew Seid, Helina Mollalign, Kirubel Eshetu, Waganeh Sinshaw, Yeshiwork Abebaw, Misikir Amare, Biniyam Dagne, Getu Diriba, Bazezew Yenew, Melak Getu, Betselot Zerihun
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Infectious Diseases
Subjects:
Rifampicin-resistance
Molecular Beacon
DNA probes
Xpert® MTB/RIF assay
Online Access:https://doi.org/10.1186/s12879-020-4817-2

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