Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review
A large amount of evidence shows that after a cancer diagnosis, patients significantly reduce their level of physical activity. Usually, this reduction is attributed to cancer-related fatigue. However, to our knowledge, no study has clearly demonstrated that fatigue alters effort-based decision-maki...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.774347/full |
| _version_ | 1819095792016687104 |
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| author | Nathalie André Nathalie André Steven Gastinger Steven Gastinger Amélie Rébillard Amélie Rébillard |
| author_facet | Nathalie André Nathalie André Steven Gastinger Steven Gastinger Amélie Rébillard Amélie Rébillard |
| author_sort | Nathalie André |
| collection | DOAJ |
| description | A large amount of evidence shows that after a cancer diagnosis, patients significantly reduce their level of physical activity. Usually, this reduction is attributed to cancer-related fatigue. However, to our knowledge, no study has clearly demonstrated that fatigue alters effort-based decision-making in cancer. This mini-review aimed to provide evidence that chronic fatigue in cancer patients causes changes in brain connectivity that impact effort-based decision-making. Indeed, three patterns of activation to compensate for dysfunctional networks have been reported: greater variability in the executive network and hyperactivation in the executive network, which account for less efficient and costly processes in the frontal cortex, and reduced deactivation in the default mode network. Nevertheless, these activation patterns are also observed with other factors, such as anticipatory stressors (worry, rumination or sleep loss), that might also cause reluctance to engage in physical activity. Effort-based decision-making involving weighing costs against benefits and physical activity interventions should increase immediate benefits to facilitate engagement in effortful activities. |
| first_indexed | 2024-12-21T23:48:55Z |
| format | Article |
| id | doaj.art-78924ee9b000487d93dc02f057824711 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T23:48:55Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-78924ee9b000487d93dc02f0578247112022-12-21T18:46:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-12-011110.3389/fonc.2021.774347774347Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-ReviewNathalie André0Nathalie André1Steven Gastinger2Steven Gastinger3Amélie Rébillard4Amélie Rébillard5Research Centre on Cognition and Learning (UMR CNRS 7295), University of Poitiers, Sport Sciences Faculty, Poitiers, FranceMaison des Sciences de l’Homme et de la Société (USR CNRS 3565), Université de Poitiers, Poitiers, FranceM2S-EA7470, University of Rennes, Rennes, FranceAPCoSS - Institut de Formation en Education Physique et en Sport (IFEPSA), UCO Angers, Angers, FranceM2S-EA7470, University of Rennes, Rennes, FranceInstitut Universitaire de France (IUF), Paris, FranceA large amount of evidence shows that after a cancer diagnosis, patients significantly reduce their level of physical activity. Usually, this reduction is attributed to cancer-related fatigue. However, to our knowledge, no study has clearly demonstrated that fatigue alters effort-based decision-making in cancer. This mini-review aimed to provide evidence that chronic fatigue in cancer patients causes changes in brain connectivity that impact effort-based decision-making. Indeed, three patterns of activation to compensate for dysfunctional networks have been reported: greater variability in the executive network and hyperactivation in the executive network, which account for less efficient and costly processes in the frontal cortex, and reduced deactivation in the default mode network. Nevertheless, these activation patterns are also observed with other factors, such as anticipatory stressors (worry, rumination or sleep loss), that might also cause reluctance to engage in physical activity. Effort-based decision-making involving weighing costs against benefits and physical activity interventions should increase immediate benefits to facilitate engagement in effortful activities.https://www.frontiersin.org/articles/10.3389/fonc.2021.774347/fullchronic fatigueimmediate benefitsfunctional connectivityphysical activityeffort-based decision makingcost-benefit analysis |
| spellingShingle | Nathalie André Nathalie André Steven Gastinger Steven Gastinger Amélie Rébillard Amélie Rébillard Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review Frontiers in Oncology chronic fatigue immediate benefits functional connectivity physical activity effort-based decision making cost-benefit analysis |
| title | Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review |
| title_full | Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review |
| title_fullStr | Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review |
| title_full_unstemmed | Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review |
| title_short | Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review |
| title_sort | chronic fatigue in cancer brain connectivity and reluctance to engage in physical activity a mini review |
| topic | chronic fatigue immediate benefits functional connectivity physical activity effort-based decision making cost-benefit analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.774347/full |
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