Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context
Background: Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM). Methods: We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnan...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-09-01
|
| Series: | EBioMedicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396418303013 |
| _version_ | 1818292712493809664 |
|---|---|
| author | Jing Li Xiaoxu Huo Yun-Feng Cao Sai-Nan Li Zuo Du Ping Shao Junhong Leng Cuiping Zhang Xiao-Yu Sun Ronald C.W. Ma Zhong-Ze Fang Xilin Yang |
| author_facet | Jing Li Xiaoxu Huo Yun-Feng Cao Sai-Nan Li Zuo Du Ping Shao Junhong Leng Cuiping Zhang Xiao-Yu Sun Ronald C.W. Ma Zhong-Ze Fang Xilin Yang |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Background: Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM). Methods: We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in China: 243 women with GDM were matched with 243 non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline were used to examine full-range associations of bile acid metabolites with GDM. Findings: All the 9 detectable bile acids were inversely associated with the risk of GDM, among them, 8 in nonlinear and one in largely linear manners in multivariable analysis. Glycoursodeoxycholic acid (GUDCA) at ≤0.07 nmol/mL and deoxycholic acid (DCA) at ≤0.28 nmol/mL had threshold effects and their decreasing levels below the cutoff points were associated with rapid rises in the risk of GDM. In traditional risk factor model, the stepwise procedure identified that GUDCA ≤ 0.07 nmol/mL and DCA ≤ 0.280 nmol/mL were still significant (OR: 6.84, 95%CI: 1.10–42.48 & 2.06, 1.26–3.37), while other bile acids were not. Inclusion of the two bile acids in the model increased the area under operating characteristic's curve from 0.69 to 0.76 (95% CI: 0.71–0.80) (P < .05). Interpretation: Serum GUDCA ≤ 0.07 nmol/mL and DCA ≤ 0.28 nmol/mL in early pregnancy were independently associated with increased risk of GDM in Chinese pregnant women. Funding: Talent Recruitment Scheme grant of Tianjin Medical University and National Key Research and Development Program, etc. Keywords: Gestational diabetes mellitus, Bile acids, Metabolomics, Early-onset marker, Metabolism |
| first_indexed | 2024-12-13T03:04:19Z |
| format | Article |
| id | doaj.art-7892b96065be48a1908f58b5c4db9471 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-13T03:04:19Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-7892b96065be48a1908f58b5c4db94712022-12-22T00:01:46ZengElsevierEBioMedicine2352-39642018-09-0135317324Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in contextJing Li0Xiaoxu Huo1Yun-Feng Cao2Sai-Nan Li3Zuo Du4Ping Shao5Junhong Leng6Cuiping Zhang7Xiao-Yu Sun8Ronald C.W. Ma9Zhong-Ze Fang10Xilin Yang11Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, ChinaKey Laboratory of Liaoning Tumor Clinical Metabolomics (KLLTCM), Jinzhou, Liaoning, China; RSKT Biopharma Inc, Dalian, Liaoning, ChinaDepartment of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Women and Children's Health Center, Tianjin, ChinaTianjin Women and Children's Health Center, Tianjin, ChinaTianjin Women and Children's Health Center, Tianjin, ChinaKey Laboratory of Liaoning Tumor Clinical Metabolomics (KLLTCM), Jinzhou, Liaoning, China; RSKT Biopharma Inc, Dalian, Liaoning, ChinaDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, China; Corresponding author at: Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China.Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China; Corresponding author at: P.O. Box 154, Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China.Background: Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM). Methods: We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in China: 243 women with GDM were matched with 243 non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline were used to examine full-range associations of bile acid metabolites with GDM. Findings: All the 9 detectable bile acids were inversely associated with the risk of GDM, among them, 8 in nonlinear and one in largely linear manners in multivariable analysis. Glycoursodeoxycholic acid (GUDCA) at ≤0.07 nmol/mL and deoxycholic acid (DCA) at ≤0.28 nmol/mL had threshold effects and their decreasing levels below the cutoff points were associated with rapid rises in the risk of GDM. In traditional risk factor model, the stepwise procedure identified that GUDCA ≤ 0.07 nmol/mL and DCA ≤ 0.280 nmol/mL were still significant (OR: 6.84, 95%CI: 1.10–42.48 & 2.06, 1.26–3.37), while other bile acids were not. Inclusion of the two bile acids in the model increased the area under operating characteristic's curve from 0.69 to 0.76 (95% CI: 0.71–0.80) (P < .05). Interpretation: Serum GUDCA ≤ 0.07 nmol/mL and DCA ≤ 0.28 nmol/mL in early pregnancy were independently associated with increased risk of GDM in Chinese pregnant women. Funding: Talent Recruitment Scheme grant of Tianjin Medical University and National Key Research and Development Program, etc. Keywords: Gestational diabetes mellitus, Bile acids, Metabolomics, Early-onset marker, Metabolismhttp://www.sciencedirect.com/science/article/pii/S2352396418303013 |
| spellingShingle | Jing Li Xiaoxu Huo Yun-Feng Cao Sai-Nan Li Zuo Du Ping Shao Junhong Leng Cuiping Zhang Xiao-Yu Sun Ronald C.W. Ma Zhong-Ze Fang Xilin Yang Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context EBioMedicine |
| title | Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context |
| title_full | Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context |
| title_fullStr | Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context |
| title_full_unstemmed | Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context |
| title_short | Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control studyResearch in context |
| title_sort | bile acid metabolites in early pregnancy and risk of gestational diabetes in chinese women a nested case control studyresearch in context |
| url | http://www.sciencedirect.com/science/article/pii/S2352396418303013 |
| work_keys_str_mv | AT jingli bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT xiaoxuhuo bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT yunfengcao bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT sainanli bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT zuodu bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT pingshao bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT junhongleng bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT cuipingzhang bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT xiaoyusun bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT ronaldcwma bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT zhongzefang bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext AT xilinyang bileacidmetabolitesinearlypregnancyandriskofgestationaldiabetesinchinesewomenanestedcasecontrolstudyresearchincontext |