Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data
Abstract Background Patients with polycythemia vera (PV) have a higher mortality risk compared with the general population, primarily driven by cardiovascular disease, thrombotic events (TEs), and hematologic transformations. The goal of risk-adapted therapy in PV is prevention of TEs. Current treat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40164-018-0107-8 |
| _version_ | 1818966468914577408 |
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| author | Dilan Paranagama Philomena Colucci Kristin A. Evans Machaon Bonafede Shreekant Parasuraman |
| author_facet | Dilan Paranagama Philomena Colucci Kristin A. Evans Machaon Bonafede Shreekant Parasuraman |
| author_sort | Dilan Paranagama |
| collection | DOAJ |
| description | Abstract Background Patients with polycythemia vera (PV) have a higher mortality risk compared with the general population, primarily driven by cardiovascular disease, thrombotic events (TEs), and hematologic transformations. The goal of risk-adapted therapy in PV is prevention of TEs. Current treatment recommendations indicate that high-risk patients (aged ≥ 60 years and/or with history of TEs) should be managed with cytoreductive medications, phlebotomy, and low-dose aspirin. This noninterventional study was conducted to describe real-world cytoreductive medication treatment in adult patients with PV, stratified by risk, in the United States. Methods This retrospective analysis used claims data from the Truven Health MarketScan® database. Inclusion criteria were ≥ 2 nondiagnostic claims for PV ≥ 30 days apart, age ≥ 18 years, continuous enrollment during the preindex period (January 1 to December 31, 2012), and continuous enrollment or death during the postindex period (January 1, 2013, to December 31, 2014). Assessments included patient demographics, clinical characteristics, and treatment with cytoreductive medications. Results A total of 2856 patients were identified for this analysis, including 1823 with high-risk PV and 1033 with low-risk PV. Mean (SD) age was 62.5 (13.5) years, and 65.9% of patients were male. Preindex comorbid conditions of interest were more common in high-risk than low-risk patients, including hypertension (65.0% vs 43.1%), type 2 diabetes (21.7% vs 10.1%), and congestive heart failure (6.6% vs 0.6%). Among patients who received preindex cytoreductive therapy, the most commonly used medications in high-risk (n = 666) and low-risk (n = 160) patients were hydroxyurea (94.7 and 87.5%, respectively), anagrelide (7.4 and 11.9%), and interferon (1.7 and 4.4%). Among patients who initiated cytoreductive therapy postindex, the most commonly used medications in high-risk (n = 100) and low-risk (n = 35) patients were hydroxyurea (97.0 and 91.4%, respectively), anagrelide (4.0 and 2.9%), and interferon (2.0 and 8.6%). Overall, 42.0% of high-risk and 18.9% of low-risk patients received cytoreductive medication during the preindex or postindex periods. Conclusions Despite consistent guideline recommendations for cytoreductive therapy in patients with high-risk PV, this analysis revealed that only a minority of these patients received cytoreductive medication. A notable proportion of high-risk patients with PV would likely benefit from a revised treatment plan that aligns with current guidelines. |
| first_indexed | 2024-12-20T13:33:23Z |
| format | Article |
| id | doaj.art-7893ab59707349769959d1b10311ef16 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-20T13:33:23Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-7893ab59707349769959d1b10311ef162022-12-21T19:39:01ZengBMCExperimental Hematology & Oncology2162-36192018-07-01711610.1186/s40164-018-0107-8Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world dataDilan Paranagama0Philomena Colucci1Kristin A. Evans2Machaon Bonafede3Shreekant Parasuraman4Incyte CorporationIncyte CorporationTruven Health Analytics, an IBM CompanyTruven Health Analytics, an IBM CompanyIncyte CorporationAbstract Background Patients with polycythemia vera (PV) have a higher mortality risk compared with the general population, primarily driven by cardiovascular disease, thrombotic events (TEs), and hematologic transformations. The goal of risk-adapted therapy in PV is prevention of TEs. Current treatment recommendations indicate that high-risk patients (aged ≥ 60 years and/or with history of TEs) should be managed with cytoreductive medications, phlebotomy, and low-dose aspirin. This noninterventional study was conducted to describe real-world cytoreductive medication treatment in adult patients with PV, stratified by risk, in the United States. Methods This retrospective analysis used claims data from the Truven Health MarketScan® database. Inclusion criteria were ≥ 2 nondiagnostic claims for PV ≥ 30 days apart, age ≥ 18 years, continuous enrollment during the preindex period (January 1 to December 31, 2012), and continuous enrollment or death during the postindex period (January 1, 2013, to December 31, 2014). Assessments included patient demographics, clinical characteristics, and treatment with cytoreductive medications. Results A total of 2856 patients were identified for this analysis, including 1823 with high-risk PV and 1033 with low-risk PV. Mean (SD) age was 62.5 (13.5) years, and 65.9% of patients were male. Preindex comorbid conditions of interest were more common in high-risk than low-risk patients, including hypertension (65.0% vs 43.1%), type 2 diabetes (21.7% vs 10.1%), and congestive heart failure (6.6% vs 0.6%). Among patients who received preindex cytoreductive therapy, the most commonly used medications in high-risk (n = 666) and low-risk (n = 160) patients were hydroxyurea (94.7 and 87.5%, respectively), anagrelide (7.4 and 11.9%), and interferon (1.7 and 4.4%). Among patients who initiated cytoreductive therapy postindex, the most commonly used medications in high-risk (n = 100) and low-risk (n = 35) patients were hydroxyurea (97.0 and 91.4%, respectively), anagrelide (4.0 and 2.9%), and interferon (2.0 and 8.6%). Overall, 42.0% of high-risk and 18.9% of low-risk patients received cytoreductive medication during the preindex or postindex periods. Conclusions Despite consistent guideline recommendations for cytoreductive therapy in patients with high-risk PV, this analysis revealed that only a minority of these patients received cytoreductive medication. A notable proportion of high-risk patients with PV would likely benefit from a revised treatment plan that aligns with current guidelines.http://link.springer.com/article/10.1186/s40164-018-0107-8AnagrelideHydroxyureaInterferonsMyeloproliferative disordersPolycythemia vera |
| spellingShingle | Dilan Paranagama Philomena Colucci Kristin A. Evans Machaon Bonafede Shreekant Parasuraman Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data Experimental Hematology & Oncology Anagrelide Hydroxyurea Interferons Myeloproliferative disorders Polycythemia vera |
| title | Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data |
| title_full | Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data |
| title_fullStr | Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data |
| title_full_unstemmed | Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data |
| title_short | Are patients with high-risk polycythemia vera receiving cytoreductive medications? A retrospective analysis of real-world data |
| title_sort | are patients with high risk polycythemia vera receiving cytoreductive medications a retrospective analysis of real world data |
| topic | Anagrelide Hydroxyurea Interferons Myeloproliferative disorders Polycythemia vera |
| url | http://link.springer.com/article/10.1186/s40164-018-0107-8 |
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