Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K
Background: To overcome low solubility of naproxen (NAP), deep eutectic solvents (DESs) based on choline chloride (ChCl) with glycerol (G) and oxalic acid (OA) as green solvents have been used up to 0.9 mole fraction of DES at T = (298.15 to 313.15) K. Methods: DESs were prepared by combinatio...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2019-09-01
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| Series: | Pharmaceutical Sciences |
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| Online Access: | https://ps.tbzmed.ac.ir/PDF/PHARM_28244_20181210170453 |
| _version_ | 1818603147104354304 |
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| author | Masumeh Mokhtarpour Hemayat Shekaari Fleming Martinez Mohammed Taghi Zafarani-Moattar |
| author_facet | Masumeh Mokhtarpour Hemayat Shekaari Fleming Martinez Mohammed Taghi Zafarani-Moattar |
| author_sort | Masumeh Mokhtarpour |
| collection | DOAJ |
| description | Background: To overcome low solubility of naproxen (NAP), deep eutectic solvents (DESs) based on choline chloride (ChCl) with glycerol (G) and oxalic acid (OA) as green solvents have been used up to 0.9 mole fraction of DES at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the two components with the molar ratios: ChCl/glycerol (1:2) and ChCl/oxalic acid (1:1). The solubility of NAP in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility in these solvents increased with increasing the weight fraction of DESs, especially in ChCl/OA. The solubility data were correlated by e-NRTL, Wilson and UNIQUAC models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were obtained. Conclusion: Oxalic acid based DES exhibits higher solubility than glycerol based DES. The thermodynamic models were successfully used to correlate solubility data. In addition, the results show that, the main contribution for NAP solubility in the aqueous DES solutions is the enthalpy. |
| first_indexed | 2024-12-16T13:18:33Z |
| format | Article |
| id | doaj.art-789451a23042483a92d01e56737df642 |
| institution | Directory Open Access Journal |
| issn | 2383-2886 |
| language | English |
| last_indexed | 2024-12-16T13:18:33Z |
| publishDate | 2019-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical Sciences |
| spelling | doaj.art-789451a23042483a92d01e56737df6422022-12-21T22:30:24ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862019-09-0125324625510.15171/PS.2019.31PHARM_28244_20181210170453Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) KMasumeh Mokhtarpour0Hemayat Shekaari1Fleming Martinez2Mohammed Taghi Zafarani-Moattar3Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia.Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Background: To overcome low solubility of naproxen (NAP), deep eutectic solvents (DESs) based on choline chloride (ChCl) with glycerol (G) and oxalic acid (OA) as green solvents have been used up to 0.9 mole fraction of DES at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the two components with the molar ratios: ChCl/glycerol (1:2) and ChCl/oxalic acid (1:1). The solubility of NAP in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility in these solvents increased with increasing the weight fraction of DESs, especially in ChCl/OA. The solubility data were correlated by e-NRTL, Wilson and UNIQUAC models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were obtained. Conclusion: Oxalic acid based DES exhibits higher solubility than glycerol based DES. The thermodynamic models were successfully used to correlate solubility data. In addition, the results show that, the main contribution for NAP solubility in the aqueous DES solutions is the enthalpy.https://ps.tbzmed.ac.ir/PDF/PHARM_28244_20181210170453Deep eutectic solventsSolubilityNaproxenActivity coefficient modelsThermodynamic properties |
| spellingShingle | Masumeh Mokhtarpour Hemayat Shekaari Fleming Martinez Mohammed Taghi Zafarani-Moattar Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K Pharmaceutical Sciences Deep eutectic solvents Solubility Naproxen Activity coefficient models Thermodynamic properties |
| title | Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K |
| title_full | Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K |
| title_fullStr | Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K |
| title_full_unstemmed | Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K |
| title_short | Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K |
| title_sort | performance of local composition models to correlate the aqueous solubility of naproxen in some choline based deep eutectic solvents at t 298 15 313 15 k |
| topic | Deep eutectic solvents Solubility Naproxen Activity coefficient models Thermodynamic properties |
| url | https://ps.tbzmed.ac.ir/PDF/PHARM_28244_20181210170453 |
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