The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients
Abstract Objective To determine the association between different antihypertensive regimens and cardiovascular disease (CVD) outcomes in hypertensive patients. Method This single center retrospective cohort study analyzed 602 hypertensive patients with complete medical records at Zhongnan Hospital o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03381-x |
| _version_ | 1827895360445480960 |
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| author | Shengnan Liu Fei Li Chao Zhang Baozhu Wei Jing Wan Hua Shao |
| author_facet | Shengnan Liu Fei Li Chao Zhang Baozhu Wei Jing Wan Hua Shao |
| author_sort | Shengnan Liu |
| collection | DOAJ |
| description | Abstract Objective To determine the association between different antihypertensive regimens and cardiovascular disease (CVD) outcomes in hypertensive patients. Method This single center retrospective cohort study analyzed 602 hypertensive patients with complete medical records at Zhongnan Hospital of Wuhan University, China, from January 2016 to November 2022. Baseline data and follow-up data of the included patients were collected, including demographic and clinical characteristics and laboratory results. Results During the 5-year follow-up period, CVD outcomes occurred in 244 hypertensive patients (40.53%). Compared with patients receiving regular antihypertensive treatment, the incidence of adverse cardiovascular events in patients receiving irregular antihypertensive treatment was significantly higher (62 [55.86%] vs 182 [37.07%], HR 1.642, 95% CI 1.227–2.197, p < 0.001). In subgroup analysis, the results showed that the incidence of CVD was not identical (χ2 = 9.170, p = 0.010). The incidence of adverse cardiovascular events was highest in the single-drug antihypertensive treatment group (43.60%), followed by the multi-drug combination group (41.51%), and lowest in the two-drug combination group (29.58%). Kaplan–Meier curve showed that hypertensive patients treated with two-drug combination antihypertensive had longer overall survival time. We further compared the incidence of CVD between standard blood pressure and intensive blood pressure control, and found no significant difference in the incidence of adverse cardiovascular events between treatment to a systolic blood pressure (SBP) target of less than 140 mmHg compared with a SBP target of less than 120 mmHg (105 [43.93%] vs 35 [29.66%], HR 1.334, 95% CI 0.908–1.961, p = 0.142). Conclusion The incidence of adverse cardiovascular events was significantly different among different antihypertension treatments. Kaplan–Meier survival curve showed that hypertensive patients receiving two-drug combination antihypertensive treatment had longer overall survival time. |
| first_indexed | 2024-03-12T22:19:52Z |
| format | Article |
| id | doaj.art-78970c59fd914b0fb7cec3fb2d512090 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-12T22:19:52Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-78970c59fd914b0fb7cec3fb2d5120902023-07-23T11:06:04ZengBMCBMC Cardiovascular Disorders1471-22612023-07-0123111210.1186/s12872-023-03381-xThe correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patientsShengnan Liu0Fei Li1Chao Zhang2Baozhu Wei3Jing Wan4Hua Shao5Department of Cardiovascular Medicine, Zhongnan Hospital of Wuhan UniversityDepartment of Cardiovascular Medicine, Zhongnan Hospital of Wuhan UniversityDepartment of Electrocardiogram, Zhongnan Hospital of Wuhan UniversityDepartment of Cardiovascular Medicine, Zhongnan Hospital of Wuhan UniversityDepartment of Cardiovascular Medicine, Zhongnan Hospital of Wuhan UniversityRenmin Hospital of Wuhan UniversityAbstract Objective To determine the association between different antihypertensive regimens and cardiovascular disease (CVD) outcomes in hypertensive patients. Method This single center retrospective cohort study analyzed 602 hypertensive patients with complete medical records at Zhongnan Hospital of Wuhan University, China, from January 2016 to November 2022. Baseline data and follow-up data of the included patients were collected, including demographic and clinical characteristics and laboratory results. Results During the 5-year follow-up period, CVD outcomes occurred in 244 hypertensive patients (40.53%). Compared with patients receiving regular antihypertensive treatment, the incidence of adverse cardiovascular events in patients receiving irregular antihypertensive treatment was significantly higher (62 [55.86%] vs 182 [37.07%], HR 1.642, 95% CI 1.227–2.197, p < 0.001). In subgroup analysis, the results showed that the incidence of CVD was not identical (χ2 = 9.170, p = 0.010). The incidence of adverse cardiovascular events was highest in the single-drug antihypertensive treatment group (43.60%), followed by the multi-drug combination group (41.51%), and lowest in the two-drug combination group (29.58%). Kaplan–Meier curve showed that hypertensive patients treated with two-drug combination antihypertensive had longer overall survival time. We further compared the incidence of CVD between standard blood pressure and intensive blood pressure control, and found no significant difference in the incidence of adverse cardiovascular events between treatment to a systolic blood pressure (SBP) target of less than 140 mmHg compared with a SBP target of less than 120 mmHg (105 [43.93%] vs 35 [29.66%], HR 1.334, 95% CI 0.908–1.961, p = 0.142). Conclusion The incidence of adverse cardiovascular events was significantly different among different antihypertension treatments. Kaplan–Meier survival curve showed that hypertensive patients receiving two-drug combination antihypertensive treatment had longer overall survival time.https://doi.org/10.1186/s12872-023-03381-xHypertensionAntihypertensive treatmentStandard blood pressure controlAdverse cardiovascular events |
| spellingShingle | Shengnan Liu Fei Li Chao Zhang Baozhu Wei Jing Wan Hua Shao The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients BMC Cardiovascular Disorders Hypertension Antihypertensive treatment Standard blood pressure control Adverse cardiovascular events |
| title | The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients |
| title_full | The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients |
| title_fullStr | The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients |
| title_full_unstemmed | The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients |
| title_short | The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients |
| title_sort | correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients |
| topic | Hypertension Antihypertensive treatment Standard blood pressure control Adverse cardiovascular events |
| url | https://doi.org/10.1186/s12872-023-03381-x |
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