SIRT1/Nrf2/NF-κB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage

SIRT1/Nrf2/NF-κB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage

<i>Background and objectives:</i> Oleanolic acid (OA) is a penta-cyclic triterpene with diverse bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti-atherosclerotic, hypolipidemic, and gastroprotective. However, its effects on hepatorenal damage remain...

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Bibliographic Details
Main Authors: Manea A. I. Alqrad, Dina S. El-Agamy, Sabrin R. M. Ibrahim, Alaa Sirwi, Hossam M. Abdallah, Essam Abdel-Sattar, Ali M. El-Halawany, Wael M. Elsaed, Gamal A. Mohamed
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Medicina
Subjects:
oleanolic acid
<i>Viscum schimperi</i>
thioacetamide
SIRT1/Nrf2/NF-κB
hepatorenal damage
Bax/Bcl-2
Online Access:https://www.mdpi.com/1648-9144/59/7/1351

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