Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism
Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drugâreceptor binding mechanism. Structural, thermal, morphological and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL),...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Journal of Pharmaceutical Analysis |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177913000683 |
| _version_ | 1818451961622560768 |
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| author | Hala H. Eldaroti Suad A. Gadir Moamen S. Refat Abdel Majid A. Adam |
| author_facet | Hala H. Eldaroti Suad A. Gadir Moamen S. Refat Abdel Majid A. Adam |
| author_sort | Hala H. Eldaroti |
| collection | DOAJ |
| description | Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drugâreceptor binding mechanism. Structural, thermal, morphological and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis; infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD); thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form. Keywords: Quinidine, Charge-transfer interaction, Powder X-ray diffraction, Morphology, Thermal analysis |
| first_indexed | 2024-12-14T21:15:31Z |
| format | Article |
| id | doaj.art-78977101567742ccaff1b39bc59246ce |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-12-14T21:15:31Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-78977101567742ccaff1b39bc59246ce2022-12-21T22:47:05ZengElsevierJournal of Pharmaceutical Analysis2095-17792014-04-01428195Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanismHala H. Eldaroti0Suad A. Gadir1Moamen S. Refat2Abdel Majid A. Adam3Department of Chemistry, Faculty of Education, Alzaeim Alazhari University, Khartoum, Sudan; Corresponding author. Tel.: +249 912998623.Department of Chemistry, Faculty of Education, Alzaeim Alazhari University, Khartoum, SudanDepartment of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, EgyptDepartment of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi ArabiaInvestigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drugâreceptor binding mechanism. Structural, thermal, morphological and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis; infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD); thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form. Keywords: Quinidine, Charge-transfer interaction, Powder X-ray diffraction, Morphology, Thermal analysishttp://www.sciencedirect.com/science/article/pii/S2095177913000683 |
| spellingShingle | Hala H. Eldaroti Suad A. Gadir Moamen S. Refat Abdel Majid A. Adam Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism Journal of Pharmaceutical Analysis |
| title | Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism |
| title_full | Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism |
| title_fullStr | Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism |
| title_full_unstemmed | Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism |
| title_short | Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism |
| title_sort | charge transfer interaction of drug quinidine with quinol picric acid and ddq spectroscopic characterization and biological activity studies towards understanding the drugareceptor mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2095177913000683 |
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