Research progress on the relationship between intestinal microecology and intestinal bowel disease
Abstract Intestinal microecology is the main component of human microecology. Intestinal microecology consists of intestinal microbiota, intestinal epithelial cells, and intestinal mucosal immune system. These components are interdependent and establish a complex interaction network that restricts e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12262 |
| _version_ | 1817996657328914432 |
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| author | Qianhui Fu Tianyuan Song Xiaoqin Ma Jian Cui |
| author_facet | Qianhui Fu Tianyuan Song Xiaoqin Ma Jian Cui |
| author_sort | Qianhui Fu |
| collection | DOAJ |
| description | Abstract Intestinal microecology is the main component of human microecology. Intestinal microecology consists of intestinal microbiota, intestinal epithelial cells, and intestinal mucosal immune system. These components are interdependent and establish a complex interaction network that restricts each other. According to the impact on the human body, there are three categories of symbiotic bacteria, opportunistic pathogens, and pathogenic bacteria. The intestinal microecology participates in digestion and absorption, and material metabolism, and inhibits the growth of pathogenic microorganisms. It also acts as the body's natural immune barrier, regulates the innate immunity of the intestine, controls the mucosal barrier function, and also participates in the intestinal epithelial cells' physiological activities such as hyperplasia or apoptosis. When the steady‐state balance of the intestinal microecology is disturbed, the existing core intestinal microbiota network changes and leads to obesity, diabetes, and many other diseases, especially irritable bowel syndrome, inflammatory bowel disease (IBD), and colorectal malignancy. Intestinal diseases, including tumors, are particularly closely related to intestinal microecology. This article systematically discusses the research progress on the relationship between IBD and intestinal microecology from the pathogenesis, treatment methods of IBD, and the changes in intestinal microbiota. |
| first_indexed | 2024-04-14T02:25:28Z |
| format | Article |
| id | doaj.art-7897feb3b11641bc926a0e67f3c29da0 |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-04-14T02:25:28Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-7897feb3b11641bc926a0e67f3c29da02022-12-22T02:17:54ZengWileyAnimal Models and Experimental Medicine2576-20952022-08-015429731010.1002/ame2.12262Research progress on the relationship between intestinal microecology and intestinal bowel diseaseQianhui Fu0Tianyuan Song1Xiaoqin Ma2Jian Cui3School of Pharmacy Minzu University of China Beijing ChinaSchool of Pharmacy Minzu University of China Beijing ChinaSchool of Pharmacy Minzu University of China Beijing ChinaSchool of Pharmacy Minzu University of China Beijing ChinaAbstract Intestinal microecology is the main component of human microecology. Intestinal microecology consists of intestinal microbiota, intestinal epithelial cells, and intestinal mucosal immune system. These components are interdependent and establish a complex interaction network that restricts each other. According to the impact on the human body, there are three categories of symbiotic bacteria, opportunistic pathogens, and pathogenic bacteria. The intestinal microecology participates in digestion and absorption, and material metabolism, and inhibits the growth of pathogenic microorganisms. It also acts as the body's natural immune barrier, regulates the innate immunity of the intestine, controls the mucosal barrier function, and also participates in the intestinal epithelial cells' physiological activities such as hyperplasia or apoptosis. When the steady‐state balance of the intestinal microecology is disturbed, the existing core intestinal microbiota network changes and leads to obesity, diabetes, and many other diseases, especially irritable bowel syndrome, inflammatory bowel disease (IBD), and colorectal malignancy. Intestinal diseases, including tumors, are particularly closely related to intestinal microecology. This article systematically discusses the research progress on the relationship between IBD and intestinal microecology from the pathogenesis, treatment methods of IBD, and the changes in intestinal microbiota.https://doi.org/10.1002/ame2.12262inflammatory bowel diseaseintestinal epithelial barrierintestinal microbiotaintestinal mucosal barrier |
| spellingShingle | Qianhui Fu Tianyuan Song Xiaoqin Ma Jian Cui Research progress on the relationship between intestinal microecology and intestinal bowel disease Animal Models and Experimental Medicine inflammatory bowel disease intestinal epithelial barrier intestinal microbiota intestinal mucosal barrier |
| title | Research progress on the relationship between intestinal microecology and intestinal bowel disease |
| title_full | Research progress on the relationship between intestinal microecology and intestinal bowel disease |
| title_fullStr | Research progress on the relationship between intestinal microecology and intestinal bowel disease |
| title_full_unstemmed | Research progress on the relationship between intestinal microecology and intestinal bowel disease |
| title_short | Research progress on the relationship between intestinal microecology and intestinal bowel disease |
| title_sort | research progress on the relationship between intestinal microecology and intestinal bowel disease |
| topic | inflammatory bowel disease intestinal epithelial barrier intestinal microbiota intestinal mucosal barrier |
| url | https://doi.org/10.1002/ame2.12262 |
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