Sphingolipid metabolism in brain insulin resistance and neurological diseases
Sphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence, and differentiation. Numerous studies have d...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-10-01
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Series: | Frontiers in Endocrinology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1243132/full |
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author | Meng Mei Maochang Liu Yan Mei Jing Zhao Yang Li |
author_facet | Meng Mei Maochang Liu Yan Mei Jing Zhao Yang Li |
author_sort | Meng Mei |
collection | DOAJ |
description | Sphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence, and differentiation. Numerous studies have demonstrated that sphingolipids are strongly associated with glucose metabolism and insulin resistance. Insulin resistance, including peripheral insulin resistance and brain insulin resistance, is closely related to the occurrence and development of many metabolic diseases. In addition to metabolic diseases, like type 2 diabetes, brain insulin resistance is also involved in the progression of neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. However, the specific mechanism of sphingolipids in brain insulin resistance has not been systematically summarized. This article reviews the involvement of sphingolipids in brain insulin resistance, highlighting the role and molecular biological mechanism of sphingolipid metabolism in cognitive dysfunctions and neuropathological abnormalities of the brain. |
first_indexed | 2024-03-11T19:41:32Z |
format | Article |
id | doaj.art-7898b6c082084566b8cdedfee6d8836e |
institution | Directory Open Access Journal |
issn | 1664-2392 |
language | English |
last_indexed | 2024-03-11T19:41:32Z |
publishDate | 2023-10-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Endocrinology |
spelling | doaj.art-7898b6c082084566b8cdedfee6d8836e2023-10-06T09:55:29ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12431321243132Sphingolipid metabolism in brain insulin resistance and neurological diseasesMeng Mei0Maochang Liu1Yan Mei2Jing Zhao3Yang Li4Department of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAdministrative Office, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence, and differentiation. Numerous studies have demonstrated that sphingolipids are strongly associated with glucose metabolism and insulin resistance. Insulin resistance, including peripheral insulin resistance and brain insulin resistance, is closely related to the occurrence and development of many metabolic diseases. In addition to metabolic diseases, like type 2 diabetes, brain insulin resistance is also involved in the progression of neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. However, the specific mechanism of sphingolipids in brain insulin resistance has not been systematically summarized. This article reviews the involvement of sphingolipids in brain insulin resistance, highlighting the role and molecular biological mechanism of sphingolipid metabolism in cognitive dysfunctions and neuropathological abnormalities of the brain.https://www.frontiersin.org/articles/10.3389/fendo.2023.1243132/fullsphingolipid metabolismbrain insulin resistanceceramidesphingosine-1-phosphateAlzheimer’s diseaseParkinson’s disease |
spellingShingle | Meng Mei Maochang Liu Yan Mei Jing Zhao Yang Li Sphingolipid metabolism in brain insulin resistance and neurological diseases Frontiers in Endocrinology sphingolipid metabolism brain insulin resistance ceramide sphingosine-1-phosphate Alzheimer’s disease Parkinson’s disease |
title | Sphingolipid metabolism in brain insulin resistance and neurological diseases |
title_full | Sphingolipid metabolism in brain insulin resistance and neurological diseases |
title_fullStr | Sphingolipid metabolism in brain insulin resistance and neurological diseases |
title_full_unstemmed | Sphingolipid metabolism in brain insulin resistance and neurological diseases |
title_short | Sphingolipid metabolism in brain insulin resistance and neurological diseases |
title_sort | sphingolipid metabolism in brain insulin resistance and neurological diseases |
topic | sphingolipid metabolism brain insulin resistance ceramide sphingosine-1-phosphate Alzheimer’s disease Parkinson’s disease |
url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1243132/full |
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