Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
Abstract Background Surgery remains the major treatment for early breast cancer (BC), but surgery itself is also a trauma which might induce alterations in lipid metabolism. The aim of this study was to investigate the changes in lipid profiles and to explore factors associated with lipid changes pr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12893-021-01396-9 |
| _version_ | 1798034857611231232 |
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| author | Tao He Zhu Wang Yunhao Wu Xinyi Zhang Xu Li Jiayuan Li Liang Du Jie Chen Qing Lv |
| author_facet | Tao He Zhu Wang Yunhao Wu Xinyi Zhang Xu Li Jiayuan Li Liang Du Jie Chen Qing Lv |
| author_sort | Tao He |
| collection | DOAJ |
| description | Abstract Background Surgery remains the major treatment for early breast cancer (BC), but surgery itself is also a trauma which might induce alterations in lipid metabolism. The aim of this study was to investigate the changes in lipid profiles and to explore factors associated with lipid changes pre- and postoperation. Methods We retrospectively analyzed the pre- and postoperative serum lipid profiles of 1934 BC patients. Results The levels of triglycerides (TG) (p < 0.001) and low-density lipoprotein cholesterol (LDL) (p < 0.001) were significantly elevated after surgery, while the levels of high-density lipoprotein cholesterol (HDL) (p < 0.001) were significantly decreased. After surgery, 27.76% of patients with preoperative ortholiposis developed dyslipidemia. Postmenopausal BC patients had a higher incidence of dyslipidemia (32.31%) after surgery than premenopausal BC patients (26.07%; p = 0.041). Additionally, patients with BMI > 24 (34.92%) had a higher incidence of dyslipidemia than patients with BMI ≤ 24 (24.84%; p = 0.001). Moreover, the magnitudes of the TG increase (p < 0.001), cholesterol (TC) increase (p = 0.013) and LDL increase (p = 0.015) in the premenopausal group were all greater than those in the postmenopausal group. After adjusting for multiple baseline covariates, preoperative hyperlipidemia and progesterone receptor (PR)-positive status were significantly associated with elevated TG, TC and LDL levels after surgery. Conclusions Serum lipid profiles of BC patients may increase after surgery, especially premenopausal patients. Additionally, postmenopausal and overweight patients may have a higher risk of being diagnosed with dyslipidemia after surgery. Therefore, lipid monitoring, dyslipidemia prevention and corresponding interventions should be taken into consideration during the perioperative period. |
| first_indexed | 2024-04-11T20:50:14Z |
| format | Article |
| id | doaj.art-789902dba79f44c182158d2594a83f77 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-04-11T20:50:14Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-789902dba79f44c182158d2594a83f772022-12-22T04:03:52ZengBMCBMC Surgery1471-24822021-11-0121111010.1186/s12893-021-01396-9Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysisTao He0Zhu Wang1Yunhao Wu2Xinyi Zhang3Xu Li4Jiayuan Li5Liang Du6Jie Chen7Qing Lv8Department of Breast Surgery, West China School of Medicine/West China Hospital, Sichuan UniversityLaboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan UniversityWest China School of Medicine/West China Hospital, Sichuan UniversityWest China School of Medicine/West China Hospital, Sichuan UniversityCenter of Biostatistics, Design, Measurement and Evaluation (CBDME), Department of Clinical Research Management, West China Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityDepartment of Breast Surgery, West China Hospital, Sichuan UniversityDepartment of Breast Surgery, West China Hospital, Sichuan UniversityAbstract Background Surgery remains the major treatment for early breast cancer (BC), but surgery itself is also a trauma which might induce alterations in lipid metabolism. The aim of this study was to investigate the changes in lipid profiles and to explore factors associated with lipid changes pre- and postoperation. Methods We retrospectively analyzed the pre- and postoperative serum lipid profiles of 1934 BC patients. Results The levels of triglycerides (TG) (p < 0.001) and low-density lipoprotein cholesterol (LDL) (p < 0.001) were significantly elevated after surgery, while the levels of high-density lipoprotein cholesterol (HDL) (p < 0.001) were significantly decreased. After surgery, 27.76% of patients with preoperative ortholiposis developed dyslipidemia. Postmenopausal BC patients had a higher incidence of dyslipidemia (32.31%) after surgery than premenopausal BC patients (26.07%; p = 0.041). Additionally, patients with BMI > 24 (34.92%) had a higher incidence of dyslipidemia than patients with BMI ≤ 24 (24.84%; p = 0.001). Moreover, the magnitudes of the TG increase (p < 0.001), cholesterol (TC) increase (p = 0.013) and LDL increase (p = 0.015) in the premenopausal group were all greater than those in the postmenopausal group. After adjusting for multiple baseline covariates, preoperative hyperlipidemia and progesterone receptor (PR)-positive status were significantly associated with elevated TG, TC and LDL levels after surgery. Conclusions Serum lipid profiles of BC patients may increase after surgery, especially premenopausal patients. Additionally, postmenopausal and overweight patients may have a higher risk of being diagnosed with dyslipidemia after surgery. Therefore, lipid monitoring, dyslipidemia prevention and corresponding interventions should be taken into consideration during the perioperative period.https://doi.org/10.1186/s12893-021-01396-9Breast cancerSurgeryDyslipidemia |
| spellingShingle | Tao He Zhu Wang Yunhao Wu Xinyi Zhang Xu Li Jiayuan Li Liang Du Jie Chen Qing Lv Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis BMC Surgery Breast cancer Surgery Dyslipidemia |
| title | Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis |
| title_full | Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis |
| title_fullStr | Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis |
| title_full_unstemmed | Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis |
| title_short | Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis |
| title_sort | lipid changes during the perioperative period in patients with early breast cancer a real world retrospective analysis |
| topic | Breast cancer Surgery Dyslipidemia |
| url | https://doi.org/10.1186/s12893-021-01396-9 |
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