Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study
Abstract The extended endocannabinoid system, also termed endocannabinoidome, participates in multiple metabolic functions in health and disease. Physical activity can both have an acute and chronic impact on endocannabinoid mediators, as does diet. In this crossover randomized controlled study, we...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10757-0 |
| _version_ | 1818238998643998720 |
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| author | Fabiola Forteza Isabelle Bourdeau-Julien Guillaume Q. Nguyen Fredy Alexander Guevara Agudelo Gabrielle Rochefort Lydiane Parent Volatiana Rakotoarivelo Perrine Feutry Cyril Martin Julie Perron Benoît Lamarche Nicolas Flamand Alain Veilleux François Billaut Vincenzo Di Marzo Frédéric Raymond |
| author_facet | Fabiola Forteza Isabelle Bourdeau-Julien Guillaume Q. Nguyen Fredy Alexander Guevara Agudelo Gabrielle Rochefort Lydiane Parent Volatiana Rakotoarivelo Perrine Feutry Cyril Martin Julie Perron Benoît Lamarche Nicolas Flamand Alain Veilleux François Billaut Vincenzo Di Marzo Frédéric Raymond |
| author_sort | Fabiola Forteza |
| collection | DOAJ |
| description | Abstract The extended endocannabinoid system, also termed endocannabinoidome, participates in multiple metabolic functions in health and disease. Physical activity can both have an acute and chronic impact on endocannabinoid mediators, as does diet. In this crossover randomized controlled study, we investigated the influence of diet on the peripheral response to acute maximal aerobic exercise in a sample of active adult women (n = 7) with no underlying metabolic conditions. We compared the impact of 7-day standardized Mediterranean diet (MedDiet) and control diet inspired by Canadian macronutrient intake (CanDiet) on endocannabinoidome and short-chain fatty acid metabolites post maximal aerobic exercise. Overall, plasmatic endocannabinoids, their congeners and some polyunsaturated fatty acids increased significantly post maximal aerobic exercise upon cessation of exercise and recovered their initial values within 1 h after exercise. Most N-acylethanolamines and polyunsaturated fatty acids increased directly after exercise when the participants had consumed the MedDiet, but not when they had consumed the CanDiet. This impact was different for monoacylglycerol endocannabinoid congeners, which in most cases reacted similarly to acute exercise while on the MedDiet or the CanDiet. Fecal microbiota was only minimally affected by the diet in this cohort. This study demonstrates that endocannabinoidome mediators respond to acute maximal aerobic exercise in a way that is dependent on the diet consumed in the week prior to exercise. |
| first_indexed | 2024-12-12T12:50:34Z |
| format | Article |
| id | doaj.art-789a5da314994a2585b3312dbf1724f1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T12:50:34Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-789a5da314994a2585b3312dbf1724f12022-12-22T00:24:00ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-10757-0Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized studyFabiola Forteza0Isabelle Bourdeau-Julien1Guillaume Q. Nguyen2Fredy Alexander Guevara Agudelo3Gabrielle Rochefort4Lydiane Parent5Volatiana Rakotoarivelo6Perrine Feutry7Cyril Martin8Julie Perron9Benoît Lamarche10Nicolas Flamand11Alain Veilleux12François Billaut13Vincenzo Di Marzo14Frédéric Raymond15Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Département de kinésiologie, Faculté de médecine, Université LavalCentre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF)Abstract The extended endocannabinoid system, also termed endocannabinoidome, participates in multiple metabolic functions in health and disease. Physical activity can both have an acute and chronic impact on endocannabinoid mediators, as does diet. In this crossover randomized controlled study, we investigated the influence of diet on the peripheral response to acute maximal aerobic exercise in a sample of active adult women (n = 7) with no underlying metabolic conditions. We compared the impact of 7-day standardized Mediterranean diet (MedDiet) and control diet inspired by Canadian macronutrient intake (CanDiet) on endocannabinoidome and short-chain fatty acid metabolites post maximal aerobic exercise. Overall, plasmatic endocannabinoids, their congeners and some polyunsaturated fatty acids increased significantly post maximal aerobic exercise upon cessation of exercise and recovered their initial values within 1 h after exercise. Most N-acylethanolamines and polyunsaturated fatty acids increased directly after exercise when the participants had consumed the MedDiet, but not when they had consumed the CanDiet. This impact was different for monoacylglycerol endocannabinoid congeners, which in most cases reacted similarly to acute exercise while on the MedDiet or the CanDiet. Fecal microbiota was only minimally affected by the diet in this cohort. This study demonstrates that endocannabinoidome mediators respond to acute maximal aerobic exercise in a way that is dependent on the diet consumed in the week prior to exercise.https://doi.org/10.1038/s41598-022-10757-0 |
| spellingShingle | Fabiola Forteza Isabelle Bourdeau-Julien Guillaume Q. Nguyen Fredy Alexander Guevara Agudelo Gabrielle Rochefort Lydiane Parent Volatiana Rakotoarivelo Perrine Feutry Cyril Martin Julie Perron Benoît Lamarche Nicolas Flamand Alain Veilleux François Billaut Vincenzo Di Marzo Frédéric Raymond Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study Scientific Reports |
| title | Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study |
| title_full | Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study |
| title_fullStr | Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study |
| title_full_unstemmed | Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study |
| title_short | Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study |
| title_sort | influence of diet on acute endocannabinoidome mediator levels post exercise in active women a crossover randomized study |
| url | https://doi.org/10.1038/s41598-022-10757-0 |
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