A Precision Medicine Agenda in Traumatic Brain Injury
Traumatic brain injury remains a leading cause of death and disability across the globe. Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the existing prediction models. Additionally, despite very promising preclinical data, randomized clinical trials (RCTs) of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.713100/full |
| _version_ | 1818286304841957376 |
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| author | Jovany Cruz Navarro Lucido L. Ponce Mejia Claudia Robertson |
| author_facet | Jovany Cruz Navarro Lucido L. Ponce Mejia Claudia Robertson |
| author_sort | Jovany Cruz Navarro |
| collection | DOAJ |
| description | Traumatic brain injury remains a leading cause of death and disability across the globe. Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the existing prediction models. Additionally, despite very promising preclinical data, randomized clinical trials (RCTs) of neuroprotective strategies in moderate and severe TBI have failed to demonstrate significant treatment effects. Better predictive models are needed, as the existing validated ones are more useful in prognosticating poor outcome and do not include biomarkers, genomics, proteonomics, metabolomics, etc. Invasive neuromonitoring long believed to be a “game changer” in the care of TBI patients have shown mixed results, and the level of evidence to support its widespread use remains insufficient. This is due in part to the extremely heterogenous nature of the disease regarding its etiology, pathology and severity. Currently, the diagnosis of traumatic brain injury (TBI) in the acute setting is centered on neurological examination and neuroimaging tools such as CT scanning and MRI, and its treatment has been largely confronted using a “one-size-fits-all” approach, that has left us with many unanswered questions. Precision medicine is an innovative approach for TBI treatment that considers individual variability in genes, environment, and lifestyle and has expanded across the medical fields. In this article, we briefly explore the field of precision medicine in TBI including biomarkers for therapeutic decision-making, multimodal neuromonitoring, and genomics. |
| first_indexed | 2024-12-13T01:22:28Z |
| format | Article |
| id | doaj.art-789a86de119b449da7ea2491d5347ffa |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T01:22:28Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-789a86de119b449da7ea2491d5347ffa2022-12-22T00:04:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.713100713100A Precision Medicine Agenda in Traumatic Brain InjuryJovany Cruz Navarro0Lucido L. Ponce Mejia1Claudia Robertson2Departments of Anesthesiology and Neurosurgery, Baylor College of Medicine, Houston, TX, United StatesDepartments of Neurosurgery and Neurology, LSU Health Science Center, New Orleans, LA, United StatesDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, United StatesTraumatic brain injury remains a leading cause of death and disability across the globe. Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the existing prediction models. Additionally, despite very promising preclinical data, randomized clinical trials (RCTs) of neuroprotective strategies in moderate and severe TBI have failed to demonstrate significant treatment effects. Better predictive models are needed, as the existing validated ones are more useful in prognosticating poor outcome and do not include biomarkers, genomics, proteonomics, metabolomics, etc. Invasive neuromonitoring long believed to be a “game changer” in the care of TBI patients have shown mixed results, and the level of evidence to support its widespread use remains insufficient. This is due in part to the extremely heterogenous nature of the disease regarding its etiology, pathology and severity. Currently, the diagnosis of traumatic brain injury (TBI) in the acute setting is centered on neurological examination and neuroimaging tools such as CT scanning and MRI, and its treatment has been largely confronted using a “one-size-fits-all” approach, that has left us with many unanswered questions. Precision medicine is an innovative approach for TBI treatment that considers individual variability in genes, environment, and lifestyle and has expanded across the medical fields. In this article, we briefly explore the field of precision medicine in TBI including biomarkers for therapeutic decision-making, multimodal neuromonitoring, and genomics.https://www.frontiersin.org/articles/10.3389/fphar.2022.713100/fullprecision medicinetraumatic brain injurybiomarkersneuromonitoringgenomics and epigenomics |
| spellingShingle | Jovany Cruz Navarro Lucido L. Ponce Mejia Claudia Robertson A Precision Medicine Agenda in Traumatic Brain Injury Frontiers in Pharmacology precision medicine traumatic brain injury biomarkers neuromonitoring genomics and epigenomics |
| title | A Precision Medicine Agenda in Traumatic Brain Injury |
| title_full | A Precision Medicine Agenda in Traumatic Brain Injury |
| title_fullStr | A Precision Medicine Agenda in Traumatic Brain Injury |
| title_full_unstemmed | A Precision Medicine Agenda in Traumatic Brain Injury |
| title_short | A Precision Medicine Agenda in Traumatic Brain Injury |
| title_sort | precision medicine agenda in traumatic brain injury |
| topic | precision medicine traumatic brain injury biomarkers neuromonitoring genomics and epigenomics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.713100/full |
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