Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review
PurposeThe purpose of this study is to evaluate the efficacy and safety of stimulating the vagus nerve in patients with disorders of consciousness (DOCs).MethodsA comprehensive systematic review was conducted, encompassing the search of databases such as PubMed, CENTRAL, EMBASE and PEDro from their...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1257378/full |
| _version_ | 1827817646474657792 |
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| author | Xiaoyang Dong Yunliang Tang Yifan Zhou Zhen Feng |
| author_facet | Xiaoyang Dong Yunliang Tang Yifan Zhou Zhen Feng |
| author_sort | Xiaoyang Dong |
| collection | DOAJ |
| description | PurposeThe purpose of this study is to evaluate the efficacy and safety of stimulating the vagus nerve in patients with disorders of consciousness (DOCs).MethodsA comprehensive systematic review was conducted, encompassing the search of databases such as PubMed, CENTRAL, EMBASE and PEDro from their inception until July 2023. Additionally, manual searches and exploration of grey literature were performed. The literature review was conducted independently by two reviewers for search strategy, selection of studies, data extraction, and judgment of evidence quality according to the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) Study Quality Scale.ResultsA total of 1,269 articles were retrieved, and 10 studies met the inclusion criteria. Among these, there were three case reports, five case series, and only two randomized controlled trials (RCTs). Preliminary studies have suggested that stimulation of vagus nerve can enhance the levels of DOCs in both vegetative state/unresponsive wakefulness state (VS/UWS) and minimally conscious state (MCS). However, due to a lack of high-quality RCTs research and evidence-based medical evidence, no definitive conclusion can be drawn regarding the intervention’s effectiveness on consciousness level. Additionally, there were no significant adverse effects observed following stimulation of vagus nerve.ConclusionA definitive conclusion cannot be drawn from this systematic review as there was a limited number of eligible studies and low-quality evidence. The findings of this systematic review can serve as a roadmap for future research on the use of stimulation of vagus nerve to facilitate recovery from DOCs. |
| first_indexed | 2024-03-12T00:37:12Z |
| format | Article |
| id | doaj.art-789b42a14b884898acec089bf2924017 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T00:37:12Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-789b42a14b884898acec089bf29240172023-09-15T09:30:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12573781257378Stimulation of vagus nerve for patients with disorders of consciousness: a systematic reviewXiaoyang DongYunliang TangYifan ZhouZhen FengPurposeThe purpose of this study is to evaluate the efficacy and safety of stimulating the vagus nerve in patients with disorders of consciousness (DOCs).MethodsA comprehensive systematic review was conducted, encompassing the search of databases such as PubMed, CENTRAL, EMBASE and PEDro from their inception until July 2023. Additionally, manual searches and exploration of grey literature were performed. The literature review was conducted independently by two reviewers for search strategy, selection of studies, data extraction, and judgment of evidence quality according to the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) Study Quality Scale.ResultsA total of 1,269 articles were retrieved, and 10 studies met the inclusion criteria. Among these, there were three case reports, five case series, and only two randomized controlled trials (RCTs). Preliminary studies have suggested that stimulation of vagus nerve can enhance the levels of DOCs in both vegetative state/unresponsive wakefulness state (VS/UWS) and minimally conscious state (MCS). However, due to a lack of high-quality RCTs research and evidence-based medical evidence, no definitive conclusion can be drawn regarding the intervention’s effectiveness on consciousness level. Additionally, there were no significant adverse effects observed following stimulation of vagus nerve.ConclusionA definitive conclusion cannot be drawn from this systematic review as there was a limited number of eligible studies and low-quality evidence. The findings of this systematic review can serve as a roadmap for future research on the use of stimulation of vagus nerve to facilitate recovery from DOCs.https://www.frontiersin.org/articles/10.3389/fnins.2023.1257378/fulldisorders of consciousnessvagus nerve stimulaitontranscutaneous auricular vagus nerve stimulationvagus nerve magnetic modulationvegetative state/unresponsive wakefulness stateminimally conscious state |
| spellingShingle | Xiaoyang Dong Yunliang Tang Yifan Zhou Zhen Feng Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review Frontiers in Neuroscience disorders of consciousness vagus nerve stimulaiton transcutaneous auricular vagus nerve stimulation vagus nerve magnetic modulation vegetative state/unresponsive wakefulness state minimally conscious state |
| title | Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review |
| title_full | Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review |
| title_fullStr | Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review |
| title_full_unstemmed | Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review |
| title_short | Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review |
| title_sort | stimulation of vagus nerve for patients with disorders of consciousness a systematic review |
| topic | disorders of consciousness vagus nerve stimulaiton transcutaneous auricular vagus nerve stimulation vagus nerve magnetic modulation vegetative state/unresponsive wakefulness state minimally conscious state |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1257378/full |
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