6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY
Purpose: To investigate, longitudinally, whether increases in markers of inflammation (CRP, sICAM-1) and endothelial dysfunction (sICAM-1, sVCAM-1) are associated with and precede the increase in pulse pressure (PP) in individuals with type-1 diabetes (DM1). Methods: Inception cohort of 277 DM1 pat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125927352/view |
| _version_ | 1811301008614096896 |
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| author | I. Ferreira P. Hovind C.G. Schalkwijk H.-H. Parving P. Rossing C.D.A. Stehouwer |
| author_facet | I. Ferreira P. Hovind C.G. Schalkwijk H.-H. Parving P. Rossing C.D.A. Stehouwer |
| author_sort | I. Ferreira |
| collection | DOAJ |
| description | Purpose: To investigate, longitudinally, whether increases in markers of inflammation (CRP, sICAM-1) and endothelial dysfunction (sICAM-1, sVCAM-1) are associated with and precede the increase in pulse pressure (PP) in individuals with type-1 diabetes (DM1).
Methods: Inception cohort of 277 DM1 patients (114 women; mean age at diagnosis: 27.5±13.8 yrs) who were consecutively admitted, upon diagnosis, between Sep’79–Aug’84 to an outpatient diabetic clinic (Gentofte, Denmark). Throughout a follow-up period of >20 yrs, patients’ PP, other risk factors, and CRP, sICAM-1 and sVCAM-1 were measured repeatedly (at 3–4 months intervals). Associations were analysed with generalized estimating equations (GEEs) and adjusted for sex, age at diagnosis, smoking, anti-hypertensive treatment and MAP.
Results: PP increased by 0.53 mmHg/yr, CRP by 0.033mg/L/yr, sICAM-1 by 1.8 ng/ml/yr and sVCAM-1 by 1.8 ng/ml/yr over the 20-yr longitudinal period (all p<0.001). Higher levels of ln-CRP, sICAM-1 and sVCAM-1 were all significantly associated with higher levels of PP: 0.53 mmHg (95%CI: 0.05–1.00), 1.09 mmHg (0.53–1.66) and 0.94 mmHg (0.40–1.48) per SD increase in marker, respectively. In addition, levels of sICAM-1 and sVCAM-1, but not ln-CRP, at any time point, were also associated with increases in PP occurring in the 2 yrs thereafter: 0.56 mmHg (0.18–0.94), 0.53 mmHg (0.17–0.90) and −0.01 mmHg (−0.38 −0.35) per SD increase in marker, respectively. Adjustments for other risk factors did not change these associations.
Conclusion: Life-course increases in low-grade inflammation/endothelial dysfunction are associated with and precede increases in PP, supporting the view of their involvement in the development of premature arterial stiffening in diabetes. |
| first_indexed | 2024-04-13T07:01:02Z |
| format | Article |
| id | doaj.art-789bc760dab74a318013bf5550411943 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-13T07:01:02Z |
| publishDate | 2009-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-789bc760dab74a318013bf55504119432022-12-22T02:57:07ZengBMCArtery Research1876-44012009-12-013410.1016/j.artres.2009.10.1666.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDYI. FerreiraP. HovindC.G. SchalkwijkH.-H. ParvingP. RossingC.D.A. StehouwerPurpose: To investigate, longitudinally, whether increases in markers of inflammation (CRP, sICAM-1) and endothelial dysfunction (sICAM-1, sVCAM-1) are associated with and precede the increase in pulse pressure (PP) in individuals with type-1 diabetes (DM1). Methods: Inception cohort of 277 DM1 patients (114 women; mean age at diagnosis: 27.5±13.8 yrs) who were consecutively admitted, upon diagnosis, between Sep’79–Aug’84 to an outpatient diabetic clinic (Gentofte, Denmark). Throughout a follow-up period of >20 yrs, patients’ PP, other risk factors, and CRP, sICAM-1 and sVCAM-1 were measured repeatedly (at 3–4 months intervals). Associations were analysed with generalized estimating equations (GEEs) and adjusted for sex, age at diagnosis, smoking, anti-hypertensive treatment and MAP. Results: PP increased by 0.53 mmHg/yr, CRP by 0.033mg/L/yr, sICAM-1 by 1.8 ng/ml/yr and sVCAM-1 by 1.8 ng/ml/yr over the 20-yr longitudinal period (all p<0.001). Higher levels of ln-CRP, sICAM-1 and sVCAM-1 were all significantly associated with higher levels of PP: 0.53 mmHg (95%CI: 0.05–1.00), 1.09 mmHg (0.53–1.66) and 0.94 mmHg (0.40–1.48) per SD increase in marker, respectively. In addition, levels of sICAM-1 and sVCAM-1, but not ln-CRP, at any time point, were also associated with increases in PP occurring in the 2 yrs thereafter: 0.56 mmHg (0.18–0.94), 0.53 mmHg (0.17–0.90) and −0.01 mmHg (−0.38 −0.35) per SD increase in marker, respectively. Adjustments for other risk factors did not change these associations. Conclusion: Life-course increases in low-grade inflammation/endothelial dysfunction are associated with and precede increases in PP, supporting the view of their involvement in the development of premature arterial stiffening in diabetes.https://www.atlantis-press.com/article/125927352/view |
| spellingShingle | I. Ferreira P. Hovind C.G. Schalkwijk H.-H. Parving P. Rossing C.D.A. Stehouwer 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY Artery Research |
| title | 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY |
| title_full | 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY |
| title_fullStr | 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY |
| title_full_unstemmed | 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY |
| title_short | 6.1 LOW-GRADE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION PRECEDE THE INCREASE IN PULSE PRESSURE IN TYPE 1 DIABETES:A 20-YEAR LONGITUDINAL STUDY |
| title_sort | 6 1 low grade inflammation and endothelial dysfunction precede the increase in pulse pressure in type 1 diabetes a 20 year longitudinal study |
| url | https://www.atlantis-press.com/article/125927352/view |
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