Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects
Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and scaffolds. However, current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regener...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-02-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23003006 |
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| author | Aleksandra A. Golebiowska Jonathon T. Intravaia Vinayak M. Sathe Sangamesh G. Kumbar Syam P. Nukavarapu |
| author_facet | Aleksandra A. Golebiowska Jonathon T. Intravaia Vinayak M. Sathe Sangamesh G. Kumbar Syam P. Nukavarapu |
| author_sort | Aleksandra A. Golebiowska |
| collection | DOAJ |
| description | Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and scaffolds. However, current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional recovery. To address these challenges, the utilization of decellularized tissues and cell-derived extracellular matrix (ECM) has emerged as a promising approach. These biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment, both in vitro and in vivo. Bioactive dECM materials provide a unique tissue-specific microenvironment that can regulate and guide cellular processes, thereby enhancing regenerative therapies. In this review, we explore the emerging frontiers of decellularized tissue-derived and cell-derived biomaterials and bio-inks in the field of tissue engineering and regenerative medicine. We discuss the need for further improvements in decellularization methods and techniques to retain structural, biological, and physicochemical characteristics of the dECM products in a way to mimic native tissues and organs. This article underscores the potential of dECM biomaterials to stimulate in situ tissue repair through chemotactic effects for the development of growth factor and cell-free tissue engineering strategies. The article also identifies the challenges and opportunities in developing sterilization and preservation methods applicable for decellularized biomaterials and grafts and their translation into clinical products. |
| first_indexed | 2024-03-09T14:46:31Z |
| format | Article |
| id | doaj.art-789ca39bf5b54527853253a4801ab4e4 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-09T14:46:31Z |
| publishDate | 2024-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-789ca39bf5b54527853253a4801ab4e42023-11-27T04:15:01ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-02-013298123Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospectsAleksandra A. Golebiowska0Jonathon T. Intravaia1Vinayak M. Sathe2Sangamesh G. Kumbar3Syam P. Nukavarapu4Department of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USADepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, 06032, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA; Department of Materials Science & Engineering, University of Connecticut, Storrs, CT, 06269, USA; Department of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, 06032, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA; Department of Materials Science & Engineering, University of Connecticut, Storrs, CT, 06269, USA; Department of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, 06032, USA; Corresponding author. Dept of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, Connecticut, 06269, USA.Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and scaffolds. However, current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional recovery. To address these challenges, the utilization of decellularized tissues and cell-derived extracellular matrix (ECM) has emerged as a promising approach. These biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment, both in vitro and in vivo. Bioactive dECM materials provide a unique tissue-specific microenvironment that can regulate and guide cellular processes, thereby enhancing regenerative therapies. In this review, we explore the emerging frontiers of decellularized tissue-derived and cell-derived biomaterials and bio-inks in the field of tissue engineering and regenerative medicine. We discuss the need for further improvements in decellularization methods and techniques to retain structural, biological, and physicochemical characteristics of the dECM products in a way to mimic native tissues and organs. This article underscores the potential of dECM biomaterials to stimulate in situ tissue repair through chemotactic effects for the development of growth factor and cell-free tissue engineering strategies. The article also identifies the challenges and opportunities in developing sterilization and preservation methods applicable for decellularized biomaterials and grafts and their translation into clinical products.http://www.sciencedirect.com/science/article/pii/S2452199X23003006Non-immune biomaterials and graftsNative micro-environmentBio-chemical cuesChemotactic abilityTissue-inksClinical therapies |
| spellingShingle | Aleksandra A. Golebiowska Jonathon T. Intravaia Vinayak M. Sathe Sangamesh G. Kumbar Syam P. Nukavarapu Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects Bioactive Materials Non-immune biomaterials and grafts Native micro-environment Bio-chemical cues Chemotactic ability Tissue-inks Clinical therapies |
| title | Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects |
| title_full | Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects |
| title_fullStr | Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects |
| title_full_unstemmed | Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects |
| title_short | Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects |
| title_sort | decellularized extracellular matrix biomaterials for regenerative therapies advances challenges and clinical prospects |
| topic | Non-immune biomaterials and grafts Native micro-environment Bio-chemical cues Chemotactic ability Tissue-inks Clinical therapies |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23003006 |
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