Cardiac Tissue Engineering for the Treatment of Myocardial Infarction
Poor cell engraftment rate is one of the primary factors limiting the effectiveness of cell transfer therapy for cardiac repair. Recent studies have shown that the combination of cell-based therapy and tissue engineering technology can improve stem cell engraftment and promote the therapeutic effect...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/8/11/153 |
| _version_ | 1797509935935782912 |
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| author | Dongmin Yu Xiaowei Wang Lei Ye |
| author_facet | Dongmin Yu Xiaowei Wang Lei Ye |
| author_sort | Dongmin Yu |
| collection | DOAJ |
| description | Poor cell engraftment rate is one of the primary factors limiting the effectiveness of cell transfer therapy for cardiac repair. Recent studies have shown that the combination of cell-based therapy and tissue engineering technology can improve stem cell engraftment and promote the therapeutic effects of the treatment for myocardial infarction. This mini-review summarizes the recent progress in cardiac tissue engineering of cardiovascular cells from differentiated human pluripotent stem cells (PSCs), highlights their therapeutic applications for the treatment of myocardial infarction, and discusses the present challenges of cardiac tissue engineering and possible future directions from a clinical perspective. |
| first_indexed | 2024-03-10T05:24:46Z |
| format | Article |
| id | doaj.art-789e67006a51439197bab40a44cbbfa8 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T05:24:46Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-789e67006a51439197bab40a44cbbfa82023-11-22T23:47:59ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-11-0181115310.3390/jcdd8110153Cardiac Tissue Engineering for the Treatment of Myocardial InfarctionDongmin Yu0Xiaowei Wang1Lei Ye2Department of Cardiovascular Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, ChinaDepartment of Cardiovascular Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, ChinaNational Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, SingaporePoor cell engraftment rate is one of the primary factors limiting the effectiveness of cell transfer therapy for cardiac repair. Recent studies have shown that the combination of cell-based therapy and tissue engineering technology can improve stem cell engraftment and promote the therapeutic effects of the treatment for myocardial infarction. This mini-review summarizes the recent progress in cardiac tissue engineering of cardiovascular cells from differentiated human pluripotent stem cells (PSCs), highlights their therapeutic applications for the treatment of myocardial infarction, and discusses the present challenges of cardiac tissue engineering and possible future directions from a clinical perspective.https://www.mdpi.com/2308-3425/8/11/153engineered cardiac tissuemyocardial infarctionstem cells |
| spellingShingle | Dongmin Yu Xiaowei Wang Lei Ye Cardiac Tissue Engineering for the Treatment of Myocardial Infarction Journal of Cardiovascular Development and Disease engineered cardiac tissue myocardial infarction stem cells |
| title | Cardiac Tissue Engineering for the Treatment of Myocardial Infarction |
| title_full | Cardiac Tissue Engineering for the Treatment of Myocardial Infarction |
| title_fullStr | Cardiac Tissue Engineering for the Treatment of Myocardial Infarction |
| title_full_unstemmed | Cardiac Tissue Engineering for the Treatment of Myocardial Infarction |
| title_short | Cardiac Tissue Engineering for the Treatment of Myocardial Infarction |
| title_sort | cardiac tissue engineering for the treatment of myocardial infarction |
| topic | engineered cardiac tissue myocardial infarction stem cells |
| url | https://www.mdpi.com/2308-3425/8/11/153 |
| work_keys_str_mv | AT dongminyu cardiactissueengineeringforthetreatmentofmyocardialinfarction AT xiaoweiwang cardiactissueengineeringforthetreatmentofmyocardialinfarction AT leiye cardiactissueengineeringforthetreatmentofmyocardialinfarction |