Derivation of Functional Dopamine Neurons from Embryonic Stem Cells
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Pharmacological treatment of PD has been a prevailing strategy. However, it has some limitations because its effectiveness g...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2007-02-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000007783464650 |
| _version_ | 1818870789222432768 |
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| author | Dae-Sung Kim Ji Young Kim Minkyung Kang Myung Soo Cho Dong-Wook Kim |
| author_facet | Dae-Sung Kim Ji Young Kim Minkyung Kang Myung Soo Cho Dong-Wook Kim |
| author_sort | Dae-Sung Kim |
| collection | DOAJ |
| description | Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Pharmacological treatment of PD has been a prevailing strategy. However, it has some limitations because its effectiveness gradually decreases and side effects develop. As an alternative, cell transplantation therapy has been tried. Although transplantation of fetal ventral mesencephalic cells looks promising for the treatment of PD in some cases, ethical and technical problems in obtaining large numbers of human fetal brain tissues also lead to difficulty in its clinical application. Our recent studies showed that a high yield of DA neurons could be derived from embryonic stem (ES) cells and they efficiently induced behavioral recovery in a PD animal model. Here we summarize methods for generation of functional DA neurons from ES cells for application to PD models. |
| first_indexed | 2024-12-19T12:12:36Z |
| format | Article |
| id | doaj.art-789e9c53ae5b492ab7eaf1fb3ce7fc5d |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-19T12:12:36Z |
| publishDate | 2007-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-789e9c53ae5b492ab7eaf1fb3ce7fc5d2022-12-21T20:22:09ZengSAGE PublishingCell Transplantation0963-68971555-38922007-02-011610.3727/000000007783464650Derivation of Functional Dopamine Neurons from Embryonic Stem CellsDae-Sung Kim0Ji Young Kim1Minkyung Kang2Myung Soo Cho3Dong-Wook Kim4Brain Korea 21 project for Medical Science, Yonsei University College of Medicine, Seoul, KoreaDepartment of Physiology, Yonsei University College of Medicine, Seoul, KoreaBrain Korea 21 project for Medical Science, Yonsei University College of Medicine, Seoul, KoreaR&D Center, Jeil Pharmaceutical Co., Ltd., KoreaBrain Korea 21 project for Medical Science, Yonsei University College of Medicine, Seoul, KoreaParkinson's disease (PD) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Pharmacological treatment of PD has been a prevailing strategy. However, it has some limitations because its effectiveness gradually decreases and side effects develop. As an alternative, cell transplantation therapy has been tried. Although transplantation of fetal ventral mesencephalic cells looks promising for the treatment of PD in some cases, ethical and technical problems in obtaining large numbers of human fetal brain tissues also lead to difficulty in its clinical application. Our recent studies showed that a high yield of DA neurons could be derived from embryonic stem (ES) cells and they efficiently induced behavioral recovery in a PD animal model. Here we summarize methods for generation of functional DA neurons from ES cells for application to PD models.https://doi.org/10.3727/000000007783464650 |
| spellingShingle | Dae-Sung Kim Ji Young Kim Minkyung Kang Myung Soo Cho Dong-Wook Kim Derivation of Functional Dopamine Neurons from Embryonic Stem Cells Cell Transplantation |
| title | Derivation of Functional Dopamine Neurons from Embryonic Stem Cells |
| title_full | Derivation of Functional Dopamine Neurons from Embryonic Stem Cells |
| title_fullStr | Derivation of Functional Dopamine Neurons from Embryonic Stem Cells |
| title_full_unstemmed | Derivation of Functional Dopamine Neurons from Embryonic Stem Cells |
| title_short | Derivation of Functional Dopamine Neurons from Embryonic Stem Cells |
| title_sort | derivation of functional dopamine neurons from embryonic stem cells |
| url | https://doi.org/10.3727/000000007783464650 |
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