The relation among steroid hormone levels, lipid profile and menopausal symptom severity
Introduction: Many postmenopausal women experience hot flashes, night sweats, non-specific emotional and psychological distresses. Our aim was to investigate the relation among steroid hormone levels, lipid profile and menopausal symptom severity using the menopause rating scale (MRS). Methods: A cr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Journal of Psychosomatic Obstetrics and Gynecology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0167482X.2017.1321633 |
| _version_ | 1797685850360774656 |
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| author | Cihan Kaya Hüseyin Cengiz Ali Yeşil Murat Ekin Levent Yaşar |
| author_facet | Cihan Kaya Hüseyin Cengiz Ali Yeşil Murat Ekin Levent Yaşar |
| author_sort | Cihan Kaya |
| collection | DOAJ |
| description | Introduction: Many postmenopausal women experience hot flashes, night sweats, non-specific emotional and psychological distresses. Our aim was to investigate the relation among steroid hormone levels, lipid profile and menopausal symptom severity using the menopause rating scale (MRS). Methods: A cross-sectional study was performed at our outpatient clinic with natural postmenopausal women. A total of 444 women were included in this study. The basic characteristics of the study population, such as age, gravidity, parity, time to menopause onset and body mass index (BMI) were recorded. Venous blood samples were collected from subjects after overnight fasting. The levels of high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride (TG), fasting plasma glucose, C-reactive protein, thyroid-stimulating hormone (TSH), cortisol, estradiol (E2), progesterone, testosterone and dehydroepiandrostenedione sulfate (DHEA-S) were analyzed. The MRS questionnaire validated for the Turkish population was used to assess the menopausal symptoms. Results: There was a statistically significant difference between mild and severe total symptom scores for TG, and elevated TG levels were observed in the severe group (p = 0.04). Elevated testosterone levels were observed with severe psychological symptom and total symptom scores. There were significant differences in progesterone level in psychological, urogenital, and total scores and lower levels were seen in severe symptom groups. There was a significant negative correlation between urogenital symptom scores and progesterone levels (p < 0.001). Discussion: Elevated levels of testosterone were related to severe psychological symptom and total menopausal symptom scores. A decrease in progesterone levels was related to high psychological, urogenital and total menopausal symptom scores. Elevated TG levels were also related to the total severe symptom scores. |
| first_indexed | 2024-03-12T00:57:16Z |
| format | Article |
| id | doaj.art-78a031e638c24c8581efcec750a66518 |
| institution | Directory Open Access Journal |
| issn | 0167-482X 1743-8942 |
| language | English |
| last_indexed | 2024-03-12T00:57:16Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Psychosomatic Obstetrics and Gynecology |
| spelling | doaj.art-78a031e638c24c8581efcec750a665182023-09-14T12:43:59ZengTaylor & Francis GroupJournal of Psychosomatic Obstetrics and Gynecology0167-482X1743-89422017-10-0138428429110.1080/0167482X.2017.13216331321633The relation among steroid hormone levels, lipid profile and menopausal symptom severityCihan Kaya0Hüseyin Cengiz1Ali Yeşil2Murat Ekin3Levent Yaşar4Bakirkoy Dr Sadi Konuk Training and Research HospitalBakirkoy Dr Sadi Konuk Training and Research HospitalErzurum Nenehatun Maternity HospitalBakirkoy Dr Sadi Konuk Training and Research HospitalBakirkoy Dr Sadi Konuk Training and Research HospitalIntroduction: Many postmenopausal women experience hot flashes, night sweats, non-specific emotional and psychological distresses. Our aim was to investigate the relation among steroid hormone levels, lipid profile and menopausal symptom severity using the menopause rating scale (MRS). Methods: A cross-sectional study was performed at our outpatient clinic with natural postmenopausal women. A total of 444 women were included in this study. The basic characteristics of the study population, such as age, gravidity, parity, time to menopause onset and body mass index (BMI) were recorded. Venous blood samples were collected from subjects after overnight fasting. The levels of high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride (TG), fasting plasma glucose, C-reactive protein, thyroid-stimulating hormone (TSH), cortisol, estradiol (E2), progesterone, testosterone and dehydroepiandrostenedione sulfate (DHEA-S) were analyzed. The MRS questionnaire validated for the Turkish population was used to assess the menopausal symptoms. Results: There was a statistically significant difference between mild and severe total symptom scores for TG, and elevated TG levels were observed in the severe group (p = 0.04). Elevated testosterone levels were observed with severe psychological symptom and total symptom scores. There were significant differences in progesterone level in psychological, urogenital, and total scores and lower levels were seen in severe symptom groups. There was a significant negative correlation between urogenital symptom scores and progesterone levels (p < 0.001). Discussion: Elevated levels of testosterone were related to severe psychological symptom and total menopausal symptom scores. A decrease in progesterone levels was related to high psychological, urogenital and total menopausal symptom scores. Elevated TG levels were also related to the total severe symptom scores.http://dx.doi.org/10.1080/0167482X.2017.1321633menopauseprogesteronetestosteronetriglyceride |
| spellingShingle | Cihan Kaya Hüseyin Cengiz Ali Yeşil Murat Ekin Levent Yaşar The relation among steroid hormone levels, lipid profile and menopausal symptom severity Journal of Psychosomatic Obstetrics and Gynecology menopause progesterone testosterone triglyceride |
| title | The relation among steroid hormone levels, lipid profile and menopausal symptom severity |
| title_full | The relation among steroid hormone levels, lipid profile and menopausal symptom severity |
| title_fullStr | The relation among steroid hormone levels, lipid profile and menopausal symptom severity |
| title_full_unstemmed | The relation among steroid hormone levels, lipid profile and menopausal symptom severity |
| title_short | The relation among steroid hormone levels, lipid profile and menopausal symptom severity |
| title_sort | relation among steroid hormone levels lipid profile and menopausal symptom severity |
| topic | menopause progesterone testosterone triglyceride |
| url | http://dx.doi.org/10.1080/0167482X.2017.1321633 |
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